Iodobenzene is shown to catalyze the 5-exo-dig cyclization of ß-alkynyl β-ketoesters under oxidative conditions that generate hypervalent iodine species in situ. The cyclopentane products contain adjacent quaternary and tertiary stereocenters which are generated with excellent diastereoselectivity.
|Number of pages||4|
|Early online date||1 Apr 2011|
|Publication status||Published - 6 May 2011|