Laser sealing for vacuum plate glass is a key step in developing the cost-effective smart vacuum-glass window for the drive towards net-zero energy buildings. In this paper, the pores, cracks, and interface with laser welding are analyzed in depth using PbO-TiO2-SiO2-RxOy system sealing solder to prepare vacuum flat glass. The microstructure of the sealing layer was analyzed by a BX41M-LED metallographic microscope, and the interfacial bonding characteristics were observed by thermal field emission scanning electron microscopy (SEM). The solder was analyzed by an energy spectrometer, and the influence of laser power, sealing temperature, and sealing speed on the gas holes and the crack sand interface separation of the sealing layer are reported. The results show that when the laser power reached 80Wat the welding speed of 2 mm/s, the bulk solder disappeared to most of the quantity and the sealing surface density was higher, due to which negligible pores and micro cracks were found. Thus, the sealing quality of the sealing layer is considered to be suitable when the temperature of 470 °C was maintained and the solder has 68.93% of Pb and 3.04% Si in the atom fraction to achieve the wet the glass substrate surface whilst improving the bonding quality.