Lectin Protein as a Promising Component to Functionalize Micelles, Liposomes and Lipid NPs against Coronavirus

Mehran Alavi, Kofi Asare-Addo, Ali Nokhodchi

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract


The outbreak of a novel strain coronavirus as the causative agent of COVID-19 pneumonia, first identified in Wuhan, China in December 2019, has resulted in considerable focus on virulence abilities of coronavirus . Lectins are natural proteins with the ability to bind specific carbohydrates related to various microorganisms, including viruses, bacteria, fungi and parasites. Lectins have the ability to agglutinate and neutralize these pathogeneses. The delivery of the encapsulated antiviral agents or vaccines across the cell membrane can be possible by functionalized micellar and liposomal formulations. In this mini-review, recent advances and challenges related to important lectins with inhibition activities against coronaviruses are presented to obtain a novel viewpoint of microformulations or nanoformulations by micellar and liposomal cell-binding carriers
Original languageEnglish
Article number580
Number of pages16
JournalBiomedicines
Volume8
Issue number12
Early online date7 Dec 2020
DOIs
Publication statusPublished - 7 Dec 2020

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