Lipid nanoparticles for dermal drug delivery

Pratibha G Kakadia, Barbara R Conway

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Lipid based drug delivery systems have been widely studied and reported over the past decade and offer a useful alternative to other colloidal drug delivery systems. Skin is a popular route of drug delivery for locally and systemically acting drugs and nanoparticles are reported as a potential formulation strategy for dermal delivery. Although the skin acts as a natural physical barrier against penetration of foreign materials, including particulates, opportunities exist for the delivery of therapeutic nanoparticles, especially in diseased and damaged skin and via appendageal routes such as the openings of hair follicles. The extent and ability of nanoparticles to penetrate into the underlying viable tissue is still the subject of debate although recent studies have identified the follicular route as the most likely route of entry; this influences the potential applications of these dosage forms as a drug delivery strategy. This paper reviews present state of art of lipid-based nanocarriers focussing on solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsions, their production methods, potential advantages and applications in dermal drug delivery.

Original languageEnglish
Pages (from-to)2823-2829
Number of pages7
JournalCurrent Pharmaceutical Design
Volume21
Issue number20
Publication statusPublished - 2015

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Nanoparticles
Lipids
Skin
Drug Delivery Systems
Pharmaceutical Preparations
Architectural Accessibility
Hair Follicle
Dosage Forms
Skin Diseases
Therapeutics

Cite this

Kakadia, Pratibha G ; Conway, Barbara R. / Lipid nanoparticles for dermal drug delivery. In: Current Pharmaceutical Design. 2015 ; Vol. 21, No. 20. pp. 2823-2829.
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Lipid nanoparticles for dermal drug delivery. / Kakadia, Pratibha G; Conway, Barbara R.

In: Current Pharmaceutical Design, Vol. 21, No. 20, 2015, p. 2823-2829.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lipid nanoparticles for dermal drug delivery

AU - Kakadia, Pratibha G

AU - Conway, Barbara R

PY - 2015

Y1 - 2015

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AB - Lipid based drug delivery systems have been widely studied and reported over the past decade and offer a useful alternative to other colloidal drug delivery systems. Skin is a popular route of drug delivery for locally and systemically acting drugs and nanoparticles are reported as a potential formulation strategy for dermal delivery. Although the skin acts as a natural physical barrier against penetration of foreign materials, including particulates, opportunities exist for the delivery of therapeutic nanoparticles, especially in diseased and damaged skin and via appendageal routes such as the openings of hair follicles. The extent and ability of nanoparticles to penetrate into the underlying viable tissue is still the subject of debate although recent studies have identified the follicular route as the most likely route of entry; this influences the potential applications of these dosage forms as a drug delivery strategy. This paper reviews present state of art of lipid-based nanocarriers focussing on solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsions, their production methods, potential advantages and applications in dermal drug delivery.

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KW - Animals

KW - Biological Transport

KW - Drug Carriers

KW - Humans

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KW - Nanoparticles

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KW - Skin Absorption

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