Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS

A.C.S Carvalho, G.A.C. Zangaro, R.P. Fernandes, B. Ekawa, A.L.C.S. Nascimento, B.F. Silva, Gage Ashton, Gareth Parkes, M. Ionashiro, F.J. Caires

Research output: Contribution to journalArticle

Abstract

In the present work, the thermal behavior of Lornoxicam drug was studied under oxidizing (air) and pyrolysis (N2) atmospheres using simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), Hot Stage Microscopy (HSM) and Evolved Gas Analysis (EGA) in the form of thermogravimetry coupled to infrared spectroscopy (TG-FTIR) and mass spectrometry (TG-MS). The thermal degradation product formed at different temperatures were examined using liquid chromatography coupled to mass spectrometry (LC–MS) and Powder X-Ray Diffraction (PXRD). The thermal study showed that the drug does not melt, partially amorphized on heating, it is thermally stable to 205 °C and undergoes thermal decomposition in two overlapping mass loss steps. Furthermore, the DSC and MS techniques suggest that thermal degradation processes are very complex, which occur with the release of gaseous products HCN, SO2, COS, CO2, N2O and CO and formation of three intermediate in the thermal residue.
LanguageEnglish
Article number178353
Number of pages8
JournalThermochimica Acta
Volume680
Early online date10 Aug 2019
DOIs
Publication statusPublished - 1 Oct 2019

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thermal degradation
pyrolysis
drugs
Pyrolysis
heat measurement
thermogravimetry
Differential scanning calorimetry
scanning
mass spectroscopy
Pharmaceutical Preparations
Mass spectrometry
Thermogravimetric analysis
gas analysis
liquid chromatography
products
Gas fuel analysis
thermal decomposition
Liquid chromatography
Carbon Monoxide
infrared spectroscopy

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Carvalho, A. C. S., Zangaro, G. A. C., Fernandes, R. P., Ekawa, B., Nascimento, A. L. C. S., Silva, B. F., ... Caires, F. J. (2019). Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS. Thermochimica Acta, 680, [178353]. https://doi.org/10.1016/j.tca.2019.178353
Carvalho, A.C.S ; Zangaro, G.A.C. ; Fernandes, R.P. ; Ekawa, B. ; Nascimento, A.L.C.S. ; Silva, B.F. ; Ashton, Gage ; Parkes, Gareth ; Ionashiro, M. ; Caires, F.J. / Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS. In: Thermochimica Acta. 2019 ; Vol. 680.
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Lornoxicam drug—A new study of thermal degradation under oxidative and pyrolysis conditions using the thermoanalytical techniques, DRX and LC-MS/MS. / Carvalho, A.C.S; Zangaro, G.A.C.; Fernandes, R.P.; Ekawa, B.; Nascimento, A.L.C.S.; Silva, B.F.; Ashton, Gage; Parkes, Gareth; Ionashiro, M.; Caires, F.J.

In: Thermochimica Acta, Vol. 680, 178353, 01.10.2019.

Research output: Contribution to journalArticle

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AU - Carvalho, A.C.S

AU - Zangaro, G.A.C.

AU - Fernandes, R.P.

AU - Ekawa, B.

AU - Nascimento, A.L.C.S.

AU - Silva, B.F.

AU - Ashton, Gage

AU - Parkes, Gareth

AU - Ionashiro, M.

AU - Caires, F.J.

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