Measles virus causes immunogenic cell death in human melanoma

O. G. Donnelly, F. Errington-Mais, L. Steele, E. Hadac, V. Jennings, K. Scott, H. Peach, R. M. Phillips, J. Bond, H. Pandha, K. Harrington, R. Vile, S. Russell, P. Selby, A. A. Melcher

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.

LanguageEnglish
Pages7-15
Number of pages9
JournalGene Therapy
Volume20
Issue number1
Early online date15 Dec 2011
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Measles virus
Melanoma
Cell Death
Adaptive Immunity
Oncolytic Virotherapy
Oncolytic Viruses
HMGB1 Protein
Interferon Type I
Innate Immunity
Randomized Controlled Trials
Cytokines
Neoplasms

Cite this

Donnelly, O. G., Errington-Mais, F., Steele, L., Hadac, E., Jennings, V., Scott, K., ... Melcher, A. A. (2013). Measles virus causes immunogenic cell death in human melanoma. Gene Therapy, 20(1), 7-15. https://doi.org/10.1038/gt.2011.205
Donnelly, O. G. ; Errington-Mais, F. ; Steele, L. ; Hadac, E. ; Jennings, V. ; Scott, K. ; Peach, H. ; Phillips, R. M. ; Bond, J. ; Pandha, H. ; Harrington, K. ; Vile, R. ; Russell, S. ; Selby, P. ; Melcher, A. A. / Measles virus causes immunogenic cell death in human melanoma. In: Gene Therapy. 2013 ; Vol. 20, No. 1. pp. 7-15.
@article{c84c5069c7754c4cbe341b9066d9ac68,
title = "Measles virus causes immunogenic cell death in human melanoma",
abstract = "Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.",
keywords = "HMGB1, immunotherapy, interferon, measles, melanoma, oncolytic",
author = "Donnelly, {O. G.} and F. Errington-Mais and L. Steele and E. Hadac and V. Jennings and K. Scott and H. Peach and Phillips, {R. M.} and J. Bond and H. Pandha and K. Harrington and R. Vile and S. Russell and P. Selby and Melcher, {A. A.}",
year = "2013",
month = "1",
doi = "10.1038/gt.2011.205",
language = "English",
volume = "20",
pages = "7--15",
journal = "Gene Therapy",
issn = "0969-7128",
publisher = "Nature Publishing Group",
number = "1",

}

Donnelly, OG, Errington-Mais, F, Steele, L, Hadac, E, Jennings, V, Scott, K, Peach, H, Phillips, RM, Bond, J, Pandha, H, Harrington, K, Vile, R, Russell, S, Selby, P & Melcher, AA 2013, 'Measles virus causes immunogenic cell death in human melanoma', Gene Therapy, vol. 20, no. 1, pp. 7-15. https://doi.org/10.1038/gt.2011.205

Measles virus causes immunogenic cell death in human melanoma. / Donnelly, O. G.; Errington-Mais, F.; Steele, L.; Hadac, E.; Jennings, V.; Scott, K.; Peach, H.; Phillips, R. M.; Bond, J.; Pandha, H.; Harrington, K.; Vile, R.; Russell, S.; Selby, P.; Melcher, A. A.

In: Gene Therapy, Vol. 20, No. 1, 01.2013, p. 7-15.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Measles virus causes immunogenic cell death in human melanoma

AU - Donnelly, O. G.

AU - Errington-Mais, F.

AU - Steele, L.

AU - Hadac, E.

AU - Jennings, V.

AU - Scott, K.

AU - Peach, H.

AU - Phillips, R. M.

AU - Bond, J.

AU - Pandha, H.

AU - Harrington, K.

AU - Vile, R.

AU - Russell, S.

AU - Selby, P.

AU - Melcher, A. A.

PY - 2013/1

Y1 - 2013/1

N2 - Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.

AB - Oncolytic viruses (OV) are promising treatments for cancer, with several currently undergoing testing in randomised clinical trials. Measles virus (MV) has not yet been tested in models of human melanoma. This study demonstrates the efficacy of MV against human melanoma. It is increasingly recognised that an essential component of therapy with OV is the recruitment of host antitumour immune responses, both innate and adaptive. MV-mediated melanoma cell death is an inflammatory process, causing the release of inflammatory cytokines including type-1 interferons and the potent danger signal HMGB1. Here, using human in vitro models, we demonstrate that MV enhances innate antitumour activity, and that MV-mediated melanoma cell death is capable of stimulating a melanoma-specific adaptive immune response.

KW - HMGB1

KW - immunotherapy

KW - interferon

KW - measles

KW - melanoma

KW - oncolytic

UR - http://www.scopus.com/inward/record.url?scp=84871985834&partnerID=8YFLogxK

UR - https://www.nature.com/gt/

U2 - 10.1038/gt.2011.205

DO - 10.1038/gt.2011.205

M3 - Article

VL - 20

SP - 7

EP - 15

JO - Gene Therapy

T2 - Gene Therapy

JF - Gene Therapy

SN - 0969-7128

IS - 1

ER -

Donnelly OG, Errington-Mais F, Steele L, Hadac E, Jennings V, Scott K et al. Measles virus causes immunogenic cell death in human melanoma. Gene Therapy. 2013 Jan;20(1):7-15. https://doi.org/10.1038/gt.2011.205