Membrane stabilizing activity: A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis

E. O. Awe, J. M. Makinde, O. A. Olajide, O. K. Wakeel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalInternational Journal of Pharmacology
Volume2
Issue number4
DOIs
Publication statusPublished - 1 Jul 2006
Externally publishedYes

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