Membrane stabilizing activity: A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis

E. O. Awe, J. M. Makinde, O. A. Olajide, O. K. Wakeel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.

LanguageEnglish
Pages447-450
Number of pages4
JournalInternational Journal of Pharmacology
Volume2
Issue number4
DOIs
Publication statusPublished - 1 Jul 2006
Externally publishedYes

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Non-Steroidal Anti-Inflammatory Agents
Hot Temperature
Membranes
Carrageenan
Plant Extracts
Erythrocyte Membrane
Acetic Acid
Analgesics
Edema
Anti-Inflammatory Agents

Cite this

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abstract = "The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.",
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Membrane stabilizing activity : A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis. / Awe, E. O.; Makinde, J. M.; Olajide, O. A.; Wakeel, O. K.

In: International Journal of Pharmacology, Vol. 2, No. 4, 01.07.2006, p. 447-450.

Research output: Contribution to journalArticle

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T1 - Membrane stabilizing activity

T2 - International Journal of Pharmacology

AU - Awe, E. O.

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AU - Olajide, O. A.

AU - Wakeel, O. K.

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