Membrane stabilizing activity: A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis

E. O. Awe; J. M. Makinde; O. A. Olajide; O. K. Wakeel

doi:10.3923/ijp.2006.447.450

Membrane stabilizing activity: A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis

E. O. Awe, J. M. Makinde, O. A. Olajide, O. K. Wakeel

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg^-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg^-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.

Original language	English
Pages (from-to)	447-450
Number of pages	4
Journal	International Journal of Pharmacology
Volume	2
Issue number	4
DOIs	https://doi.org/10.3923/ijp.2006.447.450
Publication status	Published - 1 Jul 2006
Externally published	Yes

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title = "Membrane stabilizing activity: A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis",

abstract = "The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.",

keywords = "Analgesic, Anti-inflammatory, Membrane stabilization, Russelia equisetiformis",

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AU - Awe, E. O.

AU - Makinde, J. M.

AU - Olajide, O. A.

AU - Wakeel, O. K.

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N2 - The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.

AB - The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.

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KW - Membrane stabilization

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