Abstract
The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.
| Original language | English |
|---|---|
| Pages (from-to) | 447-450 |
| Number of pages | 4 |
| Journal | International Journal of Pharmacology |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jul 2006 |
| Externally published | Yes |
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Awe, E. O., Makinde, J. M., Olajide, O. A., & Wakeel, O. K. (2006). Membrane stabilizing activity: A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis. International Journal of Pharmacology, 2(4), 447-450. https://doi.org/10.3923/ijp.2006.447.450