Abstract
The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.
| Original language | English |
|---|---|
| Pages (from-to) | 447-450 |
| Number of pages | 4 |
| Journal | International Journal of Pharmacology |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Jul 2006 |
| Externally published | Yes |
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Membrane stabilizing activity : A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis. / Awe, E. O.; Makinde, J. M.; Olajide, O. A.; Wakeel, O. K.
In: International Journal of Pharmacology, Vol. 2, No. 4, 01.07.2006, p. 447-450.Research output: Contribution to journal › Article
TY - JOUR
T1 - Membrane stabilizing activity
T2 - A possible mechanism of action for the anti-inflammatory and analgesic properties of russelia equisetiformis
AU - Awe, E. O.
AU - Makinde, J. M.
AU - Olajide, O. A.
AU - Wakeel, O. K.
PY - 2006/7/1
Y1 - 2006/7/1
N2 - The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.
AB - The Methanolic extract of the whole plant of Russelia equisetiformis (10-40 mg kg-1) produced significant (p<0.05) anti-inflammatory using carrageenan-induced rat paw oedema method. The extract significantly produced analgesic effect through inhibition of acetic acid-induced writhing and significantly (p<0.05) elevated the reaction time to thermal stimulation in mice treated with extract (10-40 mg kg-1). It also significantly (p<0.05) stabilized erythrocyte membrane subjected to heat and hypotonic-induced lyses. The anti-inflammatory and analgesic activities of the extract may be due to its membrane stabilizing action.
KW - Analgesic
KW - Anti-inflammatory
KW - Membrane stabilization
KW - Russelia equisetiformis
UR - http://www.scopus.com/inward/record.url?scp=33750355309&partnerID=8YFLogxK
U2 - 10.3923/ijp.2006.447.450
DO - 10.3923/ijp.2006.447.450
M3 - Article
AN - SCOPUS:33750355309
VL - 2
SP - 447
EP - 450
JO - International Journal of Pharmacology
JF - International Journal of Pharmacology
SN - 1811-7775
IS - 4
ER -