Memory decline in down syndrome and its relationship to iPF2alpha, a urinary marker of oxidative stress

Panagiotis Zis, Patrick McHugh, Andrew McQuillin, Domenico Praticò, Mark Dickinson, Sima Shende, Zuzana Walker, Andre Strydom

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Lipid peroxidation may be a marker of free-radical-mediated injury associated with Alzheimer's disease (AD). We aimed to investigate whether changes in lipid peroxidation is associated with cognitive decline in individuals with Down syndrome over a 4-year period.

Methods: Thirty-two adults with DS participated in a longitudinal study with urinary isoprostane 8,12-iso-iPF2alpha (iPF2alpha) assays at baseline and four years follow-up. Informants rated their functional ability and memory function and the adults with DS attempted assessments of language skills and memory. Twenty-six individuals completed assessments of memory (Modified Memory Object Task, MOMT), adaptive behavior (ABAS), and receptive vocabulary (British Picture vocabulary, BPVS) at both time-points.

Results: Overall change in iPF2alpha level was negatively correlated with change in the MOMT score (Spearman's Rho = - 0.576, p = 0.006), i.e., increased lipid peroxidation was correlated with worse memory functioning over time. An increase of $0.02 ng/mg creatinine iPF2α had good sensitivity (85.7%), positive predictive value (75%,), specificity (85.7%) and negative predictive value (92.3%) for memory decline.

Conclusion: Change in iPF2alpha over time may have potential as a biomarker for memory decline in Down syndrome and potentially also help to track progression of MCI to AD in the general population.

Original languageEnglish
Article numbere97709
Number of pages6
JournalPLoS One
Volume9
Issue number6
DOIs
Publication statusPublished - 5 Jun 2014

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