Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria

Philip Sasi, Shamus P. Burns, Catherine Waruiru, Michael English, Claire L. Hobson, Christopher G. King, Moses Mosobo, John S. Beech, Richard A. Iles, Barbara J. Boucher, Robert D. Cohen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Metabolic acidosis is a common complication of severe malaria caused by Plasmodium falciparum. The factors contributing to the acidosis were assessed in 62 children with severe falciparum malaria (cases) and in 29 control children who had recently recovered from mild or moderate malaria. The acidosis was largely caused by the accumulation of both lactic and 3-hydroxybutyric acids. The determinants of oxygen release to the tissues were also examined; although there was no difference between cases and controls in respect of 2,3-bisphosphoglycerate and mean corpuscular hemoglobin concentration, there was a marked increase in P50 in the cases, caused by pyrexia, low pH, and base deficit. There was substantial relative or actual hypoglycemia in many cases. The relationship of these observations to therapeutic strategy is discussed.
LanguageEnglish
Pages256-260
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume77
Issue number2
DOIs
Publication statusPublished - Aug 2007

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Falciparum Malaria
Acidosis
Hemoglobins
Oxygen
2,3-Diphosphoglycerate
Erythrocyte Indices
3-Hydroxybutyric Acid
Hypoglycemia
Malaria
Milk
Fever
Therapeutics

Cite this

Sasi, Philip ; Burns, Shamus P. ; Waruiru, Catherine ; English, Michael ; Hobson, Claire L. ; King, Christopher G. ; Mosobo, Moses ; Beech, John S. ; Iles, Richard A. ; Boucher, Barbara J. ; Cohen, Robert D. / Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 77, No. 2. pp. 256-260.
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abstract = "Metabolic acidosis is a common complication of severe malaria caused by Plasmodium falciparum. The factors contributing to the acidosis were assessed in 62 children with severe falciparum malaria (cases) and in 29 control children who had recently recovered from mild or moderate malaria. The acidosis was largely caused by the accumulation of both lactic and 3-hydroxybutyric acids. The determinants of oxygen release to the tissues were also examined; although there was no difference between cases and controls in respect of 2,3-bisphosphoglycerate and mean corpuscular hemoglobin concentration, there was a marked increase in P50 in the cases, caused by pyrexia, low pH, and base deficit. There was substantial relative or actual hypoglycemia in many cases. The relationship of these observations to therapeutic strategy is discussed.",
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Sasi, P, Burns, SP, Waruiru, C, English, M, Hobson, CL, King, CG, Mosobo, M, Beech, JS, Iles, RA, Boucher, BJ & Cohen, RD 2007, 'Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria', American Journal of Tropical Medicine and Hygiene, vol. 77, no. 2, pp. 256-260. https://doi.org/10.4269/ajtmh.2007.77.256

Metabolic acidosis and other determinants of hemoglobin-oxygen dissociation in severe childhood Plasmodium falciparum malaria. / Sasi, Philip; Burns, Shamus P.; Waruiru, Catherine; English, Michael; Hobson, Claire L.; King, Christopher G.; Mosobo, Moses; Beech, John S.; Iles, Richard A.; Boucher, Barbara J.; Cohen, Robert D.

In: American Journal of Tropical Medicine and Hygiene, Vol. 77, No. 2, 08.2007, p. 256-260.

Research output: Contribution to journalArticle

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