Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery

Tom Clifford, Dean M. Allerton, Meghan A. Brown, Liam Harper, Steven Horsburgh, Karen M. Keane, Emma J. Stevenson, Glyn Howatson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study examined whether beetroot juice (BTJ) would attenuate inflammation and muscle damage following a marathon. Using a double blind, independent group’s design, 34 runners(~16 previous marathons completed) consumed either BTJ or an isocaloric placebo (PLA) for3 days following a marathon. Maximal isometric voluntary contractions (MIVC),counter movement jumps (CMJ), muscle soreness, serum cytokines, leucocytosis, creatinekinase (CK), high sensitivity C-reactive protein (hs-CRP) and aspartate aminotransferase(AST) were measured pre, post, and on the 2 days after the marathon. CMJ and MIVC were reduced after the marathon (P<0.05) but no group differences were observed (P>0.05).Muscle soreness was increased in the day after the marathon (BTJ; 45±48 vs. PLA; 46±39mm) and had returned to baseline by day 2, irrespective of supplementation (P=0.694).Cytokines (Interleukin-6; IL-6, interleukin-8, tumour necrosis factor-α) were increased immediately post-marathon but apart from IL-6 had returned to baseline values by day 1 post.No interaction effects were evident for IL-6 (P=0.213). Leucocytes increased 1.7 fold after the race and remained elevated 2 days post, irrespective of supplement (P<0.0001). CKpeaked at 1 day post marathon (BTJ: 965±967 & PLA: 1141±979 IU·L-1) and like AST andhs-CRP, was still elevated 2 days after the marathon (P<0.05); however, no group differences were present for these variables. Beetroot juice did not attenuate inflammation or reduce muscle damage following a marathon, possibly because most of these indices were not markedly different from baseline values in the days after the marathon.
LanguageEnglish
Pages263-270
Number of pages8
JournalApplied Physiology, Nutrition and Metabolism
Volume42
Issue number3
Early online date9 Nov 2016
DOIs
Publication statusPublished - 1 Mar 2017
Externally publishedYes

Fingerprint

Interleukin-6
Inflammation
Muscles
Isometric Contraction
Myalgia
Placebos
Aspartate Aminotransferases
Cytokines
Leukocytosis
Interleukin-8
C-Reactive Protein
Leukocytes
Tumor Necrosis Factor-alpha
Serum

Cite this

Clifford, Tom ; Allerton, Dean M. ; Brown, Meghan A. ; Harper, Liam ; Horsburgh, Steven ; Keane, Karen M. ; Stevenson, Emma J. ; Howatson, Glyn. / Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery. In: Applied Physiology, Nutrition and Metabolism. 2017 ; Vol. 42, No. 3. pp. 263-270.
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abstract = "This study examined whether beetroot juice (BTJ) would attenuate inflammation and muscle damage following a marathon. Using a double blind, independent group’s design, 34 runners(~16 previous marathons completed) consumed either BTJ or an isocaloric placebo (PLA) for3 days following a marathon. Maximal isometric voluntary contractions (MIVC),counter movement jumps (CMJ), muscle soreness, serum cytokines, leucocytosis, creatinekinase (CK), high sensitivity C-reactive protein (hs-CRP) and aspartate aminotransferase(AST) were measured pre, post, and on the 2 days after the marathon. CMJ and MIVC were reduced after the marathon (P<0.05) but no group differences were observed (P>0.05).Muscle soreness was increased in the day after the marathon (BTJ; 45±48 vs. PLA; 46±39mm) and had returned to baseline by day 2, irrespective of supplementation (P=0.694).Cytokines (Interleukin-6; IL-6, interleukin-8, tumour necrosis factor-α) were increased immediately post-marathon but apart from IL-6 had returned to baseline values by day 1 post.No interaction effects were evident for IL-6 (P=0.213). Leucocytes increased 1.7 fold after the race and remained elevated 2 days post, irrespective of supplement (P<0.0001). CKpeaked at 1 day post marathon (BTJ: 965±967 & PLA: 1141±979 IU·L-1) and like AST andhs-CRP, was still elevated 2 days after the marathon (P<0.05); however, no group differences were present for these variables. Beetroot juice did not attenuate inflammation or reduce muscle damage following a marathon, possibly because most of these indices were not markedly different from baseline values in the days after the marathon.",
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Clifford, T, Allerton, DM, Brown, MA, Harper, L, Horsburgh, S, Keane, KM, Stevenson, EJ & Howatson, G 2017, 'Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery', Applied Physiology, Nutrition and Metabolism, vol. 42, no. 3, pp. 263-270. https://doi.org/10.1139/apnm-2016-0525

Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery. / Clifford, Tom; Allerton, Dean M.; Brown, Meghan A.; Harper, Liam; Horsburgh, Steven; Keane, Karen M.; Stevenson, Emma J.; Howatson, Glyn.

In: Applied Physiology, Nutrition and Metabolism, Vol. 42, No. 3, 01.03.2017, p. 263-270.

Research output: Contribution to journalArticle

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T1 - Minimal muscle damage after a marathon and no influence of beetroot juice on inflammation and recovery

AU - Clifford, Tom

AU - Allerton, Dean M.

AU - Brown, Meghan A.

AU - Harper, Liam

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AU - Keane, Karen M.

AU - Stevenson, Emma J.

AU - Howatson, Glyn

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N2 - This study examined whether beetroot juice (BTJ) would attenuate inflammation and muscle damage following a marathon. Using a double blind, independent group’s design, 34 runners(~16 previous marathons completed) consumed either BTJ or an isocaloric placebo (PLA) for3 days following a marathon. Maximal isometric voluntary contractions (MIVC),counter movement jumps (CMJ), muscle soreness, serum cytokines, leucocytosis, creatinekinase (CK), high sensitivity C-reactive protein (hs-CRP) and aspartate aminotransferase(AST) were measured pre, post, and on the 2 days after the marathon. CMJ and MIVC were reduced after the marathon (P<0.05) but no group differences were observed (P>0.05).Muscle soreness was increased in the day after the marathon (BTJ; 45±48 vs. PLA; 46±39mm) and had returned to baseline by day 2, irrespective of supplementation (P=0.694).Cytokines (Interleukin-6; IL-6, interleukin-8, tumour necrosis factor-α) were increased immediately post-marathon but apart from IL-6 had returned to baseline values by day 1 post.No interaction effects were evident for IL-6 (P=0.213). Leucocytes increased 1.7 fold after the race and remained elevated 2 days post, irrespective of supplement (P<0.0001). CKpeaked at 1 day post marathon (BTJ: 965±967 & PLA: 1141±979 IU·L-1) and like AST andhs-CRP, was still elevated 2 days after the marathon (P<0.05); however, no group differences were present for these variables. Beetroot juice did not attenuate inflammation or reduce muscle damage following a marathon, possibly because most of these indices were not markedly different from baseline values in the days after the marathon.

AB - This study examined whether beetroot juice (BTJ) would attenuate inflammation and muscle damage following a marathon. Using a double blind, independent group’s design, 34 runners(~16 previous marathons completed) consumed either BTJ or an isocaloric placebo (PLA) for3 days following a marathon. Maximal isometric voluntary contractions (MIVC),counter movement jumps (CMJ), muscle soreness, serum cytokines, leucocytosis, creatinekinase (CK), high sensitivity C-reactive protein (hs-CRP) and aspartate aminotransferase(AST) were measured pre, post, and on the 2 days after the marathon. CMJ and MIVC were reduced after the marathon (P<0.05) but no group differences were observed (P>0.05).Muscle soreness was increased in the day after the marathon (BTJ; 45±48 vs. PLA; 46±39mm) and had returned to baseline by day 2, irrespective of supplementation (P=0.694).Cytokines (Interleukin-6; IL-6, interleukin-8, tumour necrosis factor-α) were increased immediately post-marathon but apart from IL-6 had returned to baseline values by day 1 post.No interaction effects were evident for IL-6 (P=0.213). Leucocytes increased 1.7 fold after the race and remained elevated 2 days post, irrespective of supplement (P<0.0001). CKpeaked at 1 day post marathon (BTJ: 965±967 & PLA: 1141±979 IU·L-1) and like AST andhs-CRP, was still elevated 2 days after the marathon (P<0.05); however, no group differences were present for these variables. Beetroot juice did not attenuate inflammation or reduce muscle damage following a marathon, possibly because most of these indices were not markedly different from baseline values in the days after the marathon.

KW - Exercise recovery

KW - Neuromuscular

KW - Marathon

KW - Betalains

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JO - Applied Physiology, Nutrition and Metabolism

T2 - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

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