Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia

Maria Pala, Anna Olivieri, Alessandro Achilli, Matteo Accetturo, Ene Metspalu, Maere Reidla, Erika Tamm, Monika Karmin, Tuuli Reisberg, Baharak Hooshiar Kashani, Ugo A. Perego, Valeria Carossa, Francesca Gandini, Joana B. Pereira, Pedro Soares, Norman Angerhofer, Sergei Rychkov, Nadia Al-Zahery, Valerio Carelli, Mohammad Hossein Sanati & 12 others Massoud Houshmand, Jiři Hatina, Vincent MacAulay, Luísa Pereira, Scott R. Woodward, William Davies, Clive Gamble, Douglas Baird, Ornella Semino, Richard Villems, Antonio Torroni, Martin B. Richards

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age. European populations are believed to be, to a large extent, the descendants of the inhabitants of these refugia, and some extant mtDNA lineages can be traced to refugia in Franco-Cantabria (haplogroups H1, H3, V, and U5b1), the Italian Peninsula (U5b3), and the East European Plain (U4 and U5a). Parts of the Near East, such as the Levant, were also continuously inhabited throughout the Last Glacial Maximum, but unlike western and eastern Europe, no archaeological or genetic evidence for Late Glacial expansions into Europe from the Near East has hitherto been discovered. Here we report, on the basis of an enlarged whole-genome mitochondrial database, that a substantial, perhaps predominant, signal from mitochondrial haplogroups J and T, previously thought to have spread primarily from the Near East into Europe with the Neolithic population, may in fact reflect dispersals during the Late Glacial period, ∼19-12 thousand years (ka) ago.

LanguageEnglish
Pages915-924
Number of pages10
JournalAmerican Journal of Human Genetics
Volume90
Issue number5
Early online date3 May 2012
DOIs
Publication statusPublished - 4 May 2012

Fingerprint

Eastern Europe
Middle East
Mitochondrial DNA
Population
Mitochondrial Genome
Ice
Databases
Refugium

Cite this

Pala, Maria ; Olivieri, Anna ; Achilli, Alessandro ; Accetturo, Matteo ; Metspalu, Ene ; Reidla, Maere ; Tamm, Erika ; Karmin, Monika ; Reisberg, Tuuli ; Kashani, Baharak Hooshiar ; Perego, Ugo A. ; Carossa, Valeria ; Gandini, Francesca ; Pereira, Joana B. ; Soares, Pedro ; Angerhofer, Norman ; Rychkov, Sergei ; Al-Zahery, Nadia ; Carelli, Valerio ; Sanati, Mohammad Hossein ; Houshmand, Massoud ; Hatina, Jiři ; MacAulay, Vincent ; Pereira, Luísa ; Woodward, Scott R. ; Davies, William ; Gamble, Clive ; Baird, Douglas ; Semino, Ornella ; Villems, Richard ; Torroni, Antonio ; Richards, Martin B. / Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia. In: American Journal of Human Genetics. 2012 ; Vol. 90, No. 5. pp. 915-924.
@article{e83858db608f460e999384c8ef6a0bf6,
title = "Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia",
abstract = "Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age. European populations are believed to be, to a large extent, the descendants of the inhabitants of these refugia, and some extant mtDNA lineages can be traced to refugia in Franco-Cantabria (haplogroups H1, H3, V, and U5b1), the Italian Peninsula (U5b3), and the East European Plain (U4 and U5a). Parts of the Near East, such as the Levant, were also continuously inhabited throughout the Last Glacial Maximum, but unlike western and eastern Europe, no archaeological or genetic evidence for Late Glacial expansions into Europe from the Near East has hitherto been discovered. Here we report, on the basis of an enlarged whole-genome mitochondrial database, that a substantial, perhaps predominant, signal from mitochondrial haplogroups J and T, previously thought to have spread primarily from the Near East into Europe with the Neolithic population, may in fact reflect dispersals during the Late Glacial period, ∼19-12 thousand years (ka) ago.",
author = "Maria Pala and Anna Olivieri and Alessandro Achilli and Matteo Accetturo and Ene Metspalu and Maere Reidla and Erika Tamm and Monika Karmin and Tuuli Reisberg and Kashani, {Baharak Hooshiar} and Perego, {Ugo A.} and Valeria Carossa and Francesca Gandini and Pereira, {Joana B.} and Pedro Soares and Norman Angerhofer and Sergei Rychkov and Nadia Al-Zahery and Valerio Carelli and Sanati, {Mohammad Hossein} and Massoud Houshmand and Jiři Hatina and Vincent MacAulay and Lu{\'i}sa Pereira and Woodward, {Scott R.} and William Davies and Clive Gamble and Douglas Baird and Ornella Semino and Richard Villems and Antonio Torroni and Richards, {Martin B.}",
year = "2012",
month = "5",
day = "4",
doi = "10.1016/j.ajhg.2012.04.003",
language = "English",
volume = "90",
pages = "915--924",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "5",

}

Pala, M, Olivieri, A, Achilli, A, Accetturo, M, Metspalu, E, Reidla, M, Tamm, E, Karmin, M, Reisberg, T, Kashani, BH, Perego, UA, Carossa, V, Gandini, F, Pereira, JB, Soares, P, Angerhofer, N, Rychkov, S, Al-Zahery, N, Carelli, V, Sanati, MH, Houshmand, M, Hatina, J, MacAulay, V, Pereira, L, Woodward, SR, Davies, W, Gamble, C, Baird, D, Semino, O, Villems, R, Torroni, A & Richards, MB 2012, 'Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia', American Journal of Human Genetics, vol. 90, no. 5, pp. 915-924. https://doi.org/10.1016/j.ajhg.2012.04.003

Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia. / Pala, Maria; Olivieri, Anna; Achilli, Alessandro; Accetturo, Matteo; Metspalu, Ene; Reidla, Maere; Tamm, Erika; Karmin, Monika; Reisberg, Tuuli; Kashani, Baharak Hooshiar; Perego, Ugo A.; Carossa, Valeria; Gandini, Francesca; Pereira, Joana B.; Soares, Pedro; Angerhofer, Norman; Rychkov, Sergei; Al-Zahery, Nadia; Carelli, Valerio; Sanati, Mohammad Hossein; Houshmand, Massoud; Hatina, Jiři; MacAulay, Vincent; Pereira, Luísa; Woodward, Scott R.; Davies, William; Gamble, Clive; Baird, Douglas; Semino, Ornella; Villems, Richard; Torroni, Antonio; Richards, Martin B.

In: American Journal of Human Genetics, Vol. 90, No. 5, 04.05.2012, p. 915-924.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mitochondrial DNA Signals of Late Glacial Recolonization of Europe from Near Eastern Refugia

AU - Pala, Maria

AU - Olivieri, Anna

AU - Achilli, Alessandro

AU - Accetturo, Matteo

AU - Metspalu, Ene

AU - Reidla, Maere

AU - Tamm, Erika

AU - Karmin, Monika

AU - Reisberg, Tuuli

AU - Kashani, Baharak Hooshiar

AU - Perego, Ugo A.

AU - Carossa, Valeria

AU - Gandini, Francesca

AU - Pereira, Joana B.

AU - Soares, Pedro

AU - Angerhofer, Norman

AU - Rychkov, Sergei

AU - Al-Zahery, Nadia

AU - Carelli, Valerio

AU - Sanati, Mohammad Hossein

AU - Houshmand, Massoud

AU - Hatina, Jiři

AU - MacAulay, Vincent

AU - Pereira, Luísa

AU - Woodward, Scott R.

AU - Davies, William

AU - Gamble, Clive

AU - Baird, Douglas

AU - Semino, Ornella

AU - Villems, Richard

AU - Torroni, Antonio

AU - Richards, Martin B.

PY - 2012/5/4

Y1 - 2012/5/4

N2 - Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age. European populations are believed to be, to a large extent, the descendants of the inhabitants of these refugia, and some extant mtDNA lineages can be traced to refugia in Franco-Cantabria (haplogroups H1, H3, V, and U5b1), the Italian Peninsula (U5b3), and the East European Plain (U4 and U5a). Parts of the Near East, such as the Levant, were also continuously inhabited throughout the Last Glacial Maximum, but unlike western and eastern Europe, no archaeological or genetic evidence for Late Glacial expansions into Europe from the Near East has hitherto been discovered. Here we report, on the basis of an enlarged whole-genome mitochondrial database, that a substantial, perhaps predominant, signal from mitochondrial haplogroups J and T, previously thought to have spread primarily from the Near East into Europe with the Neolithic population, may in fact reflect dispersals during the Late Glacial period, ∼19-12 thousand years (ka) ago.

AB - Human populations, along with those of many other species, are thought to have contracted into a number of refuge areas at the height of the last Ice Age. European populations are believed to be, to a large extent, the descendants of the inhabitants of these refugia, and some extant mtDNA lineages can be traced to refugia in Franco-Cantabria (haplogroups H1, H3, V, and U5b1), the Italian Peninsula (U5b3), and the East European Plain (U4 and U5a). Parts of the Near East, such as the Levant, were also continuously inhabited throughout the Last Glacial Maximum, but unlike western and eastern Europe, no archaeological or genetic evidence for Late Glacial expansions into Europe from the Near East has hitherto been discovered. Here we report, on the basis of an enlarged whole-genome mitochondrial database, that a substantial, perhaps predominant, signal from mitochondrial haplogroups J and T, previously thought to have spread primarily from the Near East into Europe with the Neolithic population, may in fact reflect dispersals during the Late Glacial period, ∼19-12 thousand years (ka) ago.

UR - http://www.scopus.com/inward/record.url?scp=84860740251&partnerID=8YFLogxK

U2 - 10.1016/j.ajhg.2012.04.003

DO - 10.1016/j.ajhg.2012.04.003

M3 - Article

VL - 90

SP - 915

EP - 924

JO - American Journal of Human Genetics

T2 - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 5

ER -