Mitochondrial haplogroup C4c: A rare lineage entering America through the ice-free corridor?

Baharak Hooshiar Kashani, Ugo A. Perego, Anna Olivieri, Norman Angerhofer, Francesca Gandini, Valeria Carossa, Hovirag Lancioni, Ornella Semino, Scott R. Woodward, Alessandro Achilli, Antonio Torroni

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Recent analyses of mitochondrial genomes from Native Americans have brought the overall number of recognized maternal founding lineages from just four to a current count of 15. However, because of their relative low frequency, almost nothing is known for some of these lineages. This leaves a considerable void in understanding the events that led to the colonization of the Americas following the Last Glacial Maximum (LGM). In this study, we identified and completely sequenced 14 mitochondrial DNAs belonging to one extremely rare Native American lineage known as haplogroup C4c. Its age and geographical distribution raise the possibility that C4c marked the Paleo-Indian group(s) that entered North America from Beringia through the ice-free corridor between the Laurentide and Cordilleran ice sheets. The similarities in ages andgeographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indians. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalAmerican Journal of Physical Anthropology
Volume147
Issue number1
Early online date24 Oct 2011
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Fingerprint

North American Indians
Age Distribution
Ice
North America
Mitochondrial DNA
Ice Cover
phylogeny
Mitochondrial Genome
Phylogeny
colonization
Mothers
scenario
event
history
Group

Cite this

Kashani, Baharak Hooshiar ; Perego, Ugo A. ; Olivieri, Anna ; Angerhofer, Norman ; Gandini, Francesca ; Carossa, Valeria ; Lancioni, Hovirag ; Semino, Ornella ; Woodward, Scott R. ; Achilli, Alessandro ; Torroni, Antonio. / Mitochondrial haplogroup C4c : A rare lineage entering America through the ice-free corridor?. In: American Journal of Physical Anthropology. 2012 ; Vol. 147, No. 1. pp. 35-39.
@article{2e2f5db53f4f498c8aa07faa95859612,
title = "Mitochondrial haplogroup C4c: A rare lineage entering America through the ice-free corridor?",
abstract = "Recent analyses of mitochondrial genomes from Native Americans have brought the overall number of recognized maternal founding lineages from just four to a current count of 15. However, because of their relative low frequency, almost nothing is known for some of these lineages. This leaves a considerable void in understanding the events that led to the colonization of the Americas following the Last Glacial Maximum (LGM). In this study, we identified and completely sequenced 14 mitochondrial DNAs belonging to one extremely rare Native American lineage known as haplogroup C4c. Its age and geographical distribution raise the possibility that C4c marked the Paleo-Indian group(s) that entered North America from Beringia through the ice-free corridor between the Laurentide and Cordilleran ice sheets. The similarities in ages andgeographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indians. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America.",
keywords = "mitochondrial genome, mtDNA haplogroup C4c, Native Americans, Paleo-Indian migrations",
author = "Kashani, {Baharak Hooshiar} and Perego, {Ugo A.} and Anna Olivieri and Norman Angerhofer and Francesca Gandini and Valeria Carossa and Hovirag Lancioni and Ornella Semino and Woodward, {Scott R.} and Alessandro Achilli and Antonio Torroni",
year = "2012",
month = "1",
day = "1",
doi = "10.1002/ajpa.21614",
language = "English",
volume = "147",
pages = "35--39",
journal = "American Journal of Physical Anthropology",
issn = "0002-9483",
publisher = "Wiley-Liss Inc.",
number = "1",

}

Kashani, BH, Perego, UA, Olivieri, A, Angerhofer, N, Gandini, F, Carossa, V, Lancioni, H, Semino, O, Woodward, SR, Achilli, A & Torroni, A 2012, 'Mitochondrial haplogroup C4c: A rare lineage entering America through the ice-free corridor?', American Journal of Physical Anthropology, vol. 147, no. 1, pp. 35-39. https://doi.org/10.1002/ajpa.21614

Mitochondrial haplogroup C4c : A rare lineage entering America through the ice-free corridor? / Kashani, Baharak Hooshiar; Perego, Ugo A.; Olivieri, Anna; Angerhofer, Norman; Gandini, Francesca; Carossa, Valeria; Lancioni, Hovirag; Semino, Ornella; Woodward, Scott R.; Achilli, Alessandro; Torroni, Antonio.

In: American Journal of Physical Anthropology, Vol. 147, No. 1, 01.01.2012, p. 35-39.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Mitochondrial haplogroup C4c

T2 - A rare lineage entering America through the ice-free corridor?

AU - Kashani, Baharak Hooshiar

AU - Perego, Ugo A.

AU - Olivieri, Anna

AU - Angerhofer, Norman

AU - Gandini, Francesca

AU - Carossa, Valeria

AU - Lancioni, Hovirag

AU - Semino, Ornella

AU - Woodward, Scott R.

AU - Achilli, Alessandro

AU - Torroni, Antonio

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Recent analyses of mitochondrial genomes from Native Americans have brought the overall number of recognized maternal founding lineages from just four to a current count of 15. However, because of their relative low frequency, almost nothing is known for some of these lineages. This leaves a considerable void in understanding the events that led to the colonization of the Americas following the Last Glacial Maximum (LGM). In this study, we identified and completely sequenced 14 mitochondrial DNAs belonging to one extremely rare Native American lineage known as haplogroup C4c. Its age and geographical distribution raise the possibility that C4c marked the Paleo-Indian group(s) that entered North America from Beringia through the ice-free corridor between the Laurentide and Cordilleran ice sheets. The similarities in ages andgeographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indians. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America.

AB - Recent analyses of mitochondrial genomes from Native Americans have brought the overall number of recognized maternal founding lineages from just four to a current count of 15. However, because of their relative low frequency, almost nothing is known for some of these lineages. This leaves a considerable void in understanding the events that led to the colonization of the Americas following the Last Glacial Maximum (LGM). In this study, we identified and completely sequenced 14 mitochondrial DNAs belonging to one extremely rare Native American lineage known as haplogroup C4c. Its age and geographical distribution raise the possibility that C4c marked the Paleo-Indian group(s) that entered North America from Beringia through the ice-free corridor between the Laurentide and Cordilleran ice sheets. The similarities in ages andgeographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indians. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America.

KW - mitochondrial genome

KW - mtDNA haplogroup C4c

KW - Native Americans

KW - Paleo-Indian migrations

UR - http://www.scopus.com/inward/record.url?scp=83655167181&partnerID=8YFLogxK

U2 - 10.1002/ajpa.21614

DO - 10.1002/ajpa.21614

M3 - Article

C2 - 22024980

AN - SCOPUS:83655167181

VL - 147

SP - 35

EP - 39

JO - American Journal of Physical Anthropology

JF - American Journal of Physical Anthropology

SN - 0002-9483

IS - 1

ER -