Mitochondrial haplogroup C4c: A rare lineage entering America through the ice-free corridor?

Baharak Hooshiar Kashani, Ugo A. Perego, Anna Olivieri, Norman Angerhofer, Francesca Gandini, Valeria Carossa, Hovirag Lancioni, Ornella Semino, Scott R. Woodward, Alessandro Achilli, Antonio Torroni

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Recent analyses of mitochondrial genomes from Native Americans have brought the overall number of recognized maternal founding lineages from just four to a current count of 15. However, because of their relative low frequency, almost nothing is known for some of these lineages. This leaves a considerable void in understanding the events that led to the colonization of the Americas following the Last Glacial Maximum (LGM). In this study, we identified and completely sequenced 14 mitochondrial DNAs belonging to one extremely rare Native American lineage known as haplogroup C4c. Its age and geographical distribution raise the possibility that C4c marked the Paleo-Indian group(s) that entered North America from Beringia through the ice-free corridor between the Laurentide and Cordilleran ice sheets. The similarities in ages andgeographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indians. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalAmerican Journal of Physical Anthropology
Volume147
Issue number1
Early online date24 Oct 2011
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Fingerprint Dive into the research topics of 'Mitochondrial haplogroup C4c: A rare lineage entering America through the ice-free corridor?'. Together they form a unique fingerprint.

  • Cite this