Abstract
Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimumandmaximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.
| Language | English |
|---|---|
| Pages | 1230-1239 |
| Number of pages | 10 |
| Journal | Molecular Biology and Evolution |
| Volume | 34 |
| Issue number | 5 |
| Early online date | 8 Feb 2017 |
| DOIs | |
| Publication status | Published - 1 May 2017 |
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Mitogenome Diversity in Sardinians : A Genetic Window onto an Island's Past. / Olivieri, Anna; Sidore, Carlo; Achilli, Alessandro; Angius, Andrea; Posth, Cosimo; Furtwängler, Anja; Brandini, Stefania; Capodiferro, Marco Rosario; Gandini, Francesca; Zoledziewska, Magdalena; Pitzalis, Maristella; Maschio, Andrea; Busonero, Fabio; Lai, Luca; Skeates, Robin; Gradoli, Maria Giuseppina; Beckett, Jessica; Marongiu, Michele; Mazzarello, Vittorio; Marongiu, Patrizia; Rubino, Salvatore; Rito, Teresa; Macaulay, Vincent; Semino, Ornella; Pala, Maria; Abecasis, Gonçalo R.; Schlessinger, David; Conde-Sousa, Eduardo; Soares, Pedro; Richards, Martin B.; Cucca, Francesco; Torroni, Antonio.
In: Molecular Biology and Evolution, Vol. 34, No. 5, 01.05.2017, p. 1230-1239.Research output: Contribution to journal › Article
TY - JOUR
T1 - Mitogenome Diversity in Sardinians
T2 - Molecular Biology and Evolution
AU - Olivieri, Anna
AU - Sidore, Carlo
AU - Achilli, Alessandro
AU - Angius, Andrea
AU - Posth, Cosimo
AU - Furtwängler, Anja
AU - Brandini, Stefania
AU - Capodiferro, Marco Rosario
AU - Gandini, Francesca
AU - Zoledziewska, Magdalena
AU - Pitzalis, Maristella
AU - Maschio, Andrea
AU - Busonero, Fabio
AU - Lai, Luca
AU - Skeates, Robin
AU - Gradoli, Maria Giuseppina
AU - Beckett, Jessica
AU - Marongiu, Michele
AU - Mazzarello, Vittorio
AU - Marongiu, Patrizia
AU - Rubino, Salvatore
AU - Rito, Teresa
AU - Macaulay, Vincent
AU - Semino, Ornella
AU - Pala, Maria
AU - Abecasis, Gonçalo R.
AU - Schlessinger, David
AU - Conde-Sousa, Eduardo
AU - Soares, Pedro
AU - Richards, Martin B.
AU - Cucca, Francesco
AU - Torroni, Antonio
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimumandmaximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.
AB - Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimumandmaximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.
KW - Haplogroups
KW - Mitochondrial DNA phylogeny
KW - Mitochondrial genomes
KW - Origins of Europeans
KW - Prehistory of Sardinia
UR - http://www.scopus.com/inward/record.url?scp=85019115396&partnerID=8YFLogxK
U2 - 10.1093/molbev/msx082
DO - 10.1093/molbev/msx082
M3 - Article
VL - 34
SP - 1230
EP - 1239
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
SN - 0737-4038
IS - 5
ER -