Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past

Anna Olivieri, Carlo Sidore, Alessandro Achilli, Andrea Angius, Cosimo Posth, Anja Furtwängler, Stefania Brandini, Marco Rosario Capodiferro, Francesca Gandini, Magdalena Zoledziewska, Maristella Pitzalis, Andrea Maschio, Fabio Busonero, Luca Lai, Robin Skeates, Maria Giuseppina Gradoli, Jessica Beckett, Michele Marongiu, Vittorio Mazzarello, Patrizia Marongiu & 12 others Salvatore Rubino, Teresa Rito, Vincent Macaulay, Ornella Semino, Maria Pala, Gonçalo R. Abecasis, David Schlessinger, Eduardo Conde-Sousa, Pedro Soares, Martin B. Richards, Francesco Cucca, Antonio Torroni

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimumandmaximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.

LanguageEnglish
Pages1230-1239
Number of pages10
JournalMolecular Biology and Evolution
Volume34
Issue number5
Early online date8 Feb 2017
DOIs
Publication statusPublished - 1 May 2017

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Islands
Italy
Sardinia
Phylogeny
Occupations
Copper
Mesolithic
archaeological evidence
Demography
outlier
ancestry
occupation
phylogeny
demographic statistics
copper
farmers
mitochondrial genome
Farmers

Cite this

Olivieri, A., Sidore, C., Achilli, A., Angius, A., Posth, C., Furtwängler, A., ... Torroni, A. (2017). Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past. Molecular Biology and Evolution, 34(5), 1230-1239. https://doi.org/10.1093/molbev/msx082
Olivieri, Anna ; Sidore, Carlo ; Achilli, Alessandro ; Angius, Andrea ; Posth, Cosimo ; Furtwängler, Anja ; Brandini, Stefania ; Capodiferro, Marco Rosario ; Gandini, Francesca ; Zoledziewska, Magdalena ; Pitzalis, Maristella ; Maschio, Andrea ; Busonero, Fabio ; Lai, Luca ; Skeates, Robin ; Gradoli, Maria Giuseppina ; Beckett, Jessica ; Marongiu, Michele ; Mazzarello, Vittorio ; Marongiu, Patrizia ; Rubino, Salvatore ; Rito, Teresa ; Macaulay, Vincent ; Semino, Ornella ; Pala, Maria ; Abecasis, Gonçalo R. ; Schlessinger, David ; Conde-Sousa, Eduardo ; Soares, Pedro ; Richards, Martin B. ; Cucca, Francesco ; Torroni, Antonio. / Mitogenome Diversity in Sardinians : A Genetic Window onto an Island's Past. In: Molecular Biology and Evolution. 2017 ; Vol. 34, No. 5. pp. 1230-1239.
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Olivieri, A, Sidore, C, Achilli, A, Angius, A, Posth, C, Furtwängler, A, Brandini, S, Capodiferro, MR, Gandini, F, Zoledziewska, M, Pitzalis, M, Maschio, A, Busonero, F, Lai, L, Skeates, R, Gradoli, MG, Beckett, J, Marongiu, M, Mazzarello, V, Marongiu, P, Rubino, S, Rito, T, Macaulay, V, Semino, O, Pala, M, Abecasis, GR, Schlessinger, D, Conde-Sousa, E, Soares, P, Richards, MB, Cucca, F & Torroni, A 2017, 'Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past', Molecular Biology and Evolution, vol. 34, no. 5, pp. 1230-1239. https://doi.org/10.1093/molbev/msx082

Mitogenome Diversity in Sardinians : A Genetic Window onto an Island's Past. / Olivieri, Anna; Sidore, Carlo; Achilli, Alessandro; Angius, Andrea; Posth, Cosimo; Furtwängler, Anja; Brandini, Stefania; Capodiferro, Marco Rosario; Gandini, Francesca; Zoledziewska, Magdalena; Pitzalis, Maristella; Maschio, Andrea; Busonero, Fabio; Lai, Luca; Skeates, Robin; Gradoli, Maria Giuseppina; Beckett, Jessica; Marongiu, Michele; Mazzarello, Vittorio; Marongiu, Patrizia; Rubino, Salvatore; Rito, Teresa; Macaulay, Vincent; Semino, Ornella; Pala, Maria; Abecasis, Gonçalo R.; Schlessinger, David; Conde-Sousa, Eduardo; Soares, Pedro; Richards, Martin B.; Cucca, Francesco; Torroni, Antonio.

In: Molecular Biology and Evolution, Vol. 34, No. 5, 01.05.2017, p. 1230-1239.

Research output: Contribution to journalArticle

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AU - Sidore, Carlo

AU - Achilli, Alessandro

AU - Angius, Andrea

AU - Posth, Cosimo

AU - Furtwängler, Anja

AU - Brandini, Stefania

AU - Capodiferro, Marco Rosario

AU - Gandini, Francesca

AU - Zoledziewska, Magdalena

AU - Pitzalis, Maristella

AU - Maschio, Andrea

AU - Busonero, Fabio

AU - Lai, Luca

AU - Skeates, Robin

AU - Gradoli, Maria Giuseppina

AU - Beckett, Jessica

AU - Marongiu, Michele

AU - Mazzarello, Vittorio

AU - Marongiu, Patrizia

AU - Rubino, Salvatore

AU - Rito, Teresa

AU - Macaulay, Vincent

AU - Semino, Ornella

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AU - Abecasis, Gonçalo R.

AU - Schlessinger, David

AU - Conde-Sousa, Eduardo

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AU - Richards, Martin B.

AU - Cucca, Francesco

AU - Torroni, Antonio

PY - 2017/5/1

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N2 - Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimumandmaximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.

AB - Sardinians are "outliers" in the European genetic landscape and, according to paleogenomic nuclear data, the closest to early European Neolithic farmers. To learn more about their genetic ancestry, we analyzed 3,491 modern and 21 ancient mitogenomes from Sardinia. We observed that 78.4% of modern mitogenomes cluster into 89 haplogroups that most likely arose in situ. For each Sardinian-specific haplogroup (SSH), we also identified the upstream node in the phylogeny, from which non-Sardinian mitogenomes radiate. This provided minimumandmaximum time estimates for the presence of each SSH on the island. In agreement with demographic evidence, almost all SSHs coalesce in the post-Nuragic, Nuragic and Neolithic-Copper Age periods. For some rare SSHs, however, we could not dismiss the possibility that they might have been on the island prior to the Neolithic, a scenario that would be in agreement with archeological evidence of a Mesolithic occupation of Sardinia.

KW - Haplogroups

KW - Mitochondrial DNA phylogeny

KW - Mitochondrial genomes

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Olivieri A, Sidore C, Achilli A, Angius A, Posth C, Furtwängler A et al. Mitogenome Diversity in Sardinians: A Genetic Window onto an Island's Past. Molecular Biology and Evolution. 2017 May 1;34(5):1230-1239. https://doi.org/10.1093/molbev/msx082