Mitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe

Anna Olivieri, Maria Pala, Francesca Gandini, Baharak Hooshiar Kashani, Ugo A. Perego, Scott R. Woodward, Viola Grugni, Vincenza Battaglia, Ornella Semino, Alessandro Achilli, Martin B. Richards, Antonio Torroni

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe. This especially affects the phylogeny of some uncommon West Eurasian haplogroups, including I and W, whose southern European and Near Eastern components are very poorly represented, suggesting that extensive hidden phylogenetic substructure remains to be uncovered. This study expanded and re-analysed the available datasets of I and W complete mtDNA genomes, reaching a comprehensive 419 mitogenomes, and searched for precise correlations between the ages and geographical distributions of their numerous newly identified subclades with events of human dispersal which contributed to the genetic formation of modern Europeans. Our results showed that haplogroups I (within N1a1b) and W originated in the Near East during the Last Glacial Maximum or pre-warming period (the period of gradual warming between the end of the LGM, ~19 ky ago, and the beginning of the first main warming phase, ~15 ky ago) and, like the much more common haplogroups J and T, may have been involved in Late Glacial expansions starting from the Near East. Thus our data contribute to a better definition of the Late and postglacial re-peopling of Europe, providing further evidence for the scenario that major population expansions started after the Last Glacial Maximum but before Neolithic times, but also evidencing traces of diffusion events in several I and W subclades dating to the European Neolithic and restricted to Europe.

Original languageEnglish
Article numbere70492
Pages (from-to)1-12
Number of pages12
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - 31 Jul 2013

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Middle East
Mitochondrial DNA
Phylogeny
Geographical distribution
phylogeny
mitochondrial DNA
Genes
Age Distribution
Central European region
human population
Population
geographical distribution
Genome
genome
mitochondrial genome

Cite this

Olivieri, Anna ; Pala, Maria ; Gandini, Francesca ; Kashani, Baharak Hooshiar ; Perego, Ugo A. ; Woodward, Scott R. ; Grugni, Viola ; Battaglia, Vincenza ; Semino, Ornella ; Achilli, Alessandro ; Richards, Martin B. ; Torroni, Antonio. / Mitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe. In: PLoS One. 2013 ; Vol. 8, No. 7. pp. 1-12.
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abstract = "The current human mitochondrial (mtDNA) phylogeny does not equally represent all human populations but is biased in favour of representatives originally from north and central Europe. This especially affects the phylogeny of some uncommon West Eurasian haplogroups, including I and W, whose southern European and Near Eastern components are very poorly represented, suggesting that extensive hidden phylogenetic substructure remains to be uncovered. This study expanded and re-analysed the available datasets of I and W complete mtDNA genomes, reaching a comprehensive 419 mitogenomes, and searched for precise correlations between the ages and geographical distributions of their numerous newly identified subclades with events of human dispersal which contributed to the genetic formation of modern Europeans. Our results showed that haplogroups I (within N1a1b) and W originated in the Near East during the Last Glacial Maximum or pre-warming period (the period of gradual warming between the end of the LGM, ~19 ky ago, and the beginning of the first main warming phase, ~15 ky ago) and, like the much more common haplogroups J and T, may have been involved in Late Glacial expansions starting from the Near East. Thus our data contribute to a better definition of the Late and postglacial re-peopling of Europe, providing further evidence for the scenario that major population expansions started after the Last Glacial Maximum but before Neolithic times, but also evidencing traces of diffusion events in several I and W subclades dating to the European Neolithic and restricted to Europe.",
author = "Anna Olivieri and Maria Pala and Francesca Gandini and Kashani, {Baharak Hooshiar} and Perego, {Ugo A.} and Woodward, {Scott R.} and Viola Grugni and Vincenza Battaglia and Ornella Semino and Alessandro Achilli and Richards, {Martin B.} and Antonio Torroni",
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Olivieri, A, Pala, M, Gandini, F, Kashani, BH, Perego, UA, Woodward, SR, Grugni, V, Battaglia, V, Semino, O, Achilli, A, Richards, MB & Torroni, A 2013, 'Mitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe', PLoS One, vol. 8, no. 7, e70492, pp. 1-12. https://doi.org/10.1371/journal.pone.0070492

Mitogenomes from Two Uncommon Haplogroups Mark Late Glacial/Postglacial Expansions from the Near East and Neolithic Dispersals within Europe. / Olivieri, Anna; Pala, Maria; Gandini, Francesca; Kashani, Baharak Hooshiar; Perego, Ugo A.; Woodward, Scott R.; Grugni, Viola; Battaglia, Vincenza; Semino, Ornella; Achilli, Alessandro; Richards, Martin B.; Torroni, Antonio.

In: PLoS One, Vol. 8, No. 7, e70492, 31.07.2013, p. 1-12.

Research output: Contribution to journalArticle

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AU - Grugni, Viola

AU - Battaglia, Vincenza

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AU - Achilli, Alessandro

AU - Richards, Martin B.

AU - Torroni, Antonio

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