A mechanical molecular spring isolator (MMSI) is proposed for the purpose of isolating the low-frequency vibration of a heavy payload. The MMSI is a passive vibration isolation technique mimicking molecular spring isolator characteristics of high-static-low-dynamic stiffness (HSLDS). An MMSI consists of a piston-cylinder container filled with the liquid and some hydraulic spring accumulators. The piston would support a lump of mass and be subjected to a specific external vibration excitation force. Those accumulators can get intercommunication by the liquid to produce the transformation from high static stiffness to low dynamic stiffness. The stiffness model of the MMSI with several identical accumulators is established based on the hydrostatic law. After that, some parameters that significantly influence the stiffness characteristics are studied. Results show that the stiffness property of this kind of MMSI demonstrates a piecewise linearity of three segments. It applies the averaging method to acquire amplitude-frequency and phase-frequency relationships of the piecewise linear vibration isolation system. An inevitable jump phenomenon may occur when the exciting force reaches the critical value. The vibration isolation performance is evaluated by energy transmissibility. Finally, an experimental prototype was designed to carry out quasi-static and dynamic experiments to verify the stiffness model and the dynamic properties as an HSLDS vibration isolator.