Modelling of tirapazamine effects on solid tumour morphology

N. Kazmi, M. A. Hossain, R. M. Phillips

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We presented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive drugs, Tirapazamine (TPZ) which is in clinical trials I and II. We calculated solid tumour mass in our previous work and then integrated that model with TPZ infusion. We calculated TPZ cytotoxicity, concentration, penetration with increasing distance from blood vessel and offered resistance from microenvironments for drug penetration inside the tumour while considering each cell as an individual entity. The impact of these factors on tumour morphology is also showed to see the drug behaviour inside animals/humans tumours. We maintained the heterogeneity factors in presented model as observed in real tumour mass especially in terms of cells proliferation, cell movement, extracellular matrix (ECM) interaction, and the gradients of partial oxygen pressure (pO2) inside tumour cells during the whole growth and treatment activity. The results suggest that TPZ high concentration in combination with chemotherapy should be given to get maximum abnormal cell killing. This model can be a good choice for oncologists and researchers to explore more about TPZ action inside solid tumour.

Original languageEnglish
Title of host publication5th International Conference on Practical Applications of Computational Biology and Bioinformatics (PACBB 2011)
Pages125-132
Number of pages8
Volume93
ISBN (Electronic)9783642199141
DOIs
Publication statusPublished - 2011
Externally publishedYes

Publication series

NameAdvances in Intelligent and Soft Computing
Volume93
ISSN (Print)18675662

    Fingerprint

Cite this

Kazmi, N., Hossain, M. A., & Phillips, R. M. (2011). Modelling of tirapazamine effects on solid tumour morphology. In 5th International Conference on Practical Applications of Computational Biology and Bioinformatics (PACBB 2011) (Vol. 93, pp. 125-132). (Advances in Intelligent and Soft Computing; Vol. 93). https://doi.org/10.1007/978-3-642-19914-1_18