Modelling skin permeability with micellar liquid chromatography

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study evaluates the potential application of micellar liquid chromatography (MLC) to predict skin permeation with a series of model compounds. MLC has previously been found to be useful in the prediction of partition coefficient values (log P) for pharmaceutical compounds, yet has not been incorporated in skin permeability models prior to this work. This article provides statistically supported data that this technique enhances the ability to predict the permeability of similar drugs through the skin (Kp). The replacement of a traditional physicochemical parameter, namely the octanol-water partition coefficient (log Pow) with a chromatographically determined value (log Pmw), results in a quantitative partition-permeability relationship that is robust to variation. MLC offers many benefits compared with the traditional techniques employed to obtain log P values.

LanguageEnglish
Pages335-340
Number of pages6
JournalEuropean Journal of Pharmaceutical Sciences
Volume50
Issue number3-4
DOIs
Publication statusPublished - 2013

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Liquid Chromatography
Permeability
Skin
Octanols
Pharmaceutical Preparations
Water

Cite this

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abstract = "This study evaluates the potential application of micellar liquid chromatography (MLC) to predict skin permeation with a series of model compounds. MLC has previously been found to be useful in the prediction of partition coefficient values (log P) for pharmaceutical compounds, yet has not been incorporated in skin permeability models prior to this work. This article provides statistically supported data that this technique enhances the ability to predict the permeability of similar drugs through the skin (Kp). The replacement of a traditional physicochemical parameter, namely the octanol-water partition coefficient (log Pow) with a chromatographically determined value (log Pmw), results in a quantitative partition-permeability relationship that is robust to variation. MLC offers many benefits compared with the traditional techniques employed to obtain log P values.",
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Modelling skin permeability with micellar liquid chromatography. / Waters, Laura J.; Shahzad, Yasser; Stephenson, John.

In: European Journal of Pharmaceutical Sciences, Vol. 50, No. 3-4, 2013, p. 335-340.

Research output: Contribution to journalArticle

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T1 - Modelling skin permeability with micellar liquid chromatography

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AU - Shahzad, Yasser

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