Modification of drug delivery to improve antibiotic targeting to the stomach

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The obstacles to the successful eradication of Helicobacter pylori infections include the presence of antibiotic-resistant bacteria and therapy requiring multiple drugs with complicated dosing schedules. Other obstacles include bacterial residence in an environment where high antibiotic concentrations are difficult to achieve. Biofilm production by the bacteria is an additional challenge to the effective treatment of this infection. Conventional oral formulations used in the treatment of this infection have a short gastric residence time, thus limiting the duration of exposure of drug to the bacteria. This review summarizes the current research in the development of gastroretentive formulations and the prospective future applications of this approach in the targeted delivery of drugs such as antibiotics to the stomach.

LanguageEnglish
Pages741-762
Number of pages22
JournalTherapeutic Delivery
Volume6
Issue number6
DOIs
Publication statusPublished - 1 Jul 2015

Fingerprint

Stomach
Anti-Bacterial Agents
Bacteria
Pharmaceutical Preparations
Helicobacter Infections
Biofilms
Infection
Helicobacter pylori
Appointments and Schedules
Research
Therapeutics

Cite this

@article{c8d6b73e3e6544eb8e4c217076412c8e,
title = "Modification of drug delivery to improve antibiotic targeting to the stomach",
abstract = "The obstacles to the successful eradication of Helicobacter pylori infections include the presence of antibiotic-resistant bacteria and therapy requiring multiple drugs with complicated dosing schedules. Other obstacles include bacterial residence in an environment where high antibiotic concentrations are difficult to achieve. Biofilm production by the bacteria is an additional challenge to the effective treatment of this infection. Conventional oral formulations used in the treatment of this infection have a short gastric residence time, thus limiting the duration of exposure of drug to the bacteria. This review summarizes the current research in the development of gastroretentive formulations and the prospective future applications of this approach in the targeted delivery of drugs such as antibiotics to the stomach.",
author = "Adebisi, {Adeola O.} and Conway, {Barbara R.}",
year = "2015",
month = "7",
day = "1",
doi = "10.4155/tde.15.35",
language = "English",
volume = "6",
pages = "741--762",
journal = "Therapeutic Delivery",
issn = "2041-5990",
publisher = "Future Science",
number = "6",

}

Modification of drug delivery to improve antibiotic targeting to the stomach. / Adebisi, Adeola O.; Conway, Barbara R.

In: Therapeutic Delivery, Vol. 6, No. 6, 01.07.2015, p. 741-762.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Modification of drug delivery to improve antibiotic targeting to the stomach

AU - Adebisi, Adeola O.

AU - Conway, Barbara R.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - The obstacles to the successful eradication of Helicobacter pylori infections include the presence of antibiotic-resistant bacteria and therapy requiring multiple drugs with complicated dosing schedules. Other obstacles include bacterial residence in an environment where high antibiotic concentrations are difficult to achieve. Biofilm production by the bacteria is an additional challenge to the effective treatment of this infection. Conventional oral formulations used in the treatment of this infection have a short gastric residence time, thus limiting the duration of exposure of drug to the bacteria. This review summarizes the current research in the development of gastroretentive formulations and the prospective future applications of this approach in the targeted delivery of drugs such as antibiotics to the stomach.

AB - The obstacles to the successful eradication of Helicobacter pylori infections include the presence of antibiotic-resistant bacteria and therapy requiring multiple drugs with complicated dosing schedules. Other obstacles include bacterial residence in an environment where high antibiotic concentrations are difficult to achieve. Biofilm production by the bacteria is an additional challenge to the effective treatment of this infection. Conventional oral formulations used in the treatment of this infection have a short gastric residence time, thus limiting the duration of exposure of drug to the bacteria. This review summarizes the current research in the development of gastroretentive formulations and the prospective future applications of this approach in the targeted delivery of drugs such as antibiotics to the stomach.

UR - http://www.scopus.com/inward/record.url?scp=84936934517&partnerID=8YFLogxK

U2 - 10.4155/tde.15.35

DO - 10.4155/tde.15.35

M3 - Review article

VL - 6

SP - 741

EP - 762

JO - Therapeutic Delivery

T2 - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

IS - 6

ER -