Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands: Synthesis, molecular and anti-cancer studies

Mahesh Kalidasan, Scott Forbes, Yurij Mozharivskyj, Maryam Ahmadi, Zeynab Ahmadihosseini, Roger M. Phillips, Mohan Rao Kollipara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Mononuclear cationic half-sandwich arene Ru(II) and Cp *Rh(III)/Cp*Ir(III) compounds with the general formula [(η6-arene)Ru(L)Cl]+ and [Cp *M(L)Cl]+ have been isolated by the reaction of bithiazole ligands {2,2′-dimethyl-4,4′-bithiazole (dm4bt), 2,2′-diamino-4,4′-bithiazole (da4bt), and 2,2′-diphenyl-4, 4′-bithiazole (dp4bt)} with the precursor compounds [(η6- arene)Ru(μ-Cl)Cl]2 (arene = C6H6, p- iPrC6H4Me or C6Me6) and [Cp*M(μ-Cl)Cl]2 (M = Rh, Ir). These compounds were isolated as SbF6 salts and fully characterized by spectral studies. Some representative compounds were confirmed by single crystal X-ray crystallographic studies. Chemo-sensitivity activities of compounds 1, 5, 11, 12, 14 and 15 were evaluated against two human breast carcinoma cell lines (MDA-MB-231 and T47D). There is a clear SAR seen, where the iridium-based complexes with the dp4bt ligand are much more potent than the ruthenium and rhodium complexes.

LanguageEnglish
Pages349-358
Number of pages10
JournalInorganica Chimica Acta
Volume421
Early online date3 Jul 2014
DOIs
Publication statusPublished - 1 Sep 2014
Externally publishedYes

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Coordination Complexes
Metal complexes
Platinum
platinum
cancer
Ligands
multiple docking adapters
Iridium
Rhodium
ligands
Ruthenium
synthesis
iridium
rhodium
cultured cells
breast
metals
ruthenium
Salts
Cells

Cite this

Kalidasan, Mahesh ; Forbes, Scott ; Mozharivskyj, Yurij ; Ahmadi, Maryam ; Ahmadihosseini, Zeynab ; Phillips, Roger M. ; Kollipara, Mohan Rao. / Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands : Synthesis, molecular and anti-cancer studies. In: Inorganica Chimica Acta. 2014 ; Vol. 421. pp. 349-358.
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Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands : Synthesis, molecular and anti-cancer studies. / Kalidasan, Mahesh; Forbes, Scott; Mozharivskyj, Yurij; Ahmadi, Maryam; Ahmadihosseini, Zeynab; Phillips, Roger M.; Kollipara, Mohan Rao.

In: Inorganica Chimica Acta, Vol. 421, 01.09.2014, p. 349-358.

Research output: Contribution to journalArticle

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T1 - Mononuclear half-sandwich cyclic-π-perimeter platinum group metal complexes having bithiazole ligands

T2 - Inorganica Chimica Acta

AU - Kalidasan, Mahesh

AU - Forbes, Scott

AU - Mozharivskyj, Yurij

AU - Ahmadi, Maryam

AU - Ahmadihosseini, Zeynab

AU - Phillips, Roger M.

AU - Kollipara, Mohan Rao

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AB - Mononuclear cationic half-sandwich arene Ru(II) and Cp *Rh(III)/Cp*Ir(III) compounds with the general formula [(η6-arene)Ru(L)Cl]+ and [Cp *M(L)Cl]+ have been isolated by the reaction of bithiazole ligands {2,2′-dimethyl-4,4′-bithiazole (dm4bt), 2,2′-diamino-4,4′-bithiazole (da4bt), and 2,2′-diphenyl-4, 4′-bithiazole (dp4bt)} with the precursor compounds [(η6- arene)Ru(μ-Cl)Cl]2 (arene = C6H6, p- iPrC6H4Me or C6Me6) and [Cp*M(μ-Cl)Cl]2 (M = Rh, Ir). These compounds were isolated as SbF6 salts and fully characterized by spectral studies. Some representative compounds were confirmed by single crystal X-ray crystallographic studies. Chemo-sensitivity activities of compounds 1, 5, 11, 12, 14 and 15 were evaluated against two human breast carcinoma cell lines (MDA-MB-231 and T47D). There is a clear SAR seen, where the iridium-based complexes with the dp4bt ligand are much more potent than the ruthenium and rhodium complexes.

KW - Arene ligands

KW - Bithiazole

KW - Iridium

KW - Rhodium

KW - Ruthenium

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