Moonlighting enzymes in parasitic protozoa

Peter W. Collingridge, Robert W.B. Brown, Michael L. Ginger

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Enzymes moonlight in a non-enzymatic capacity in a diverse variety of cellular processes. The discovery of these non-enzymatic functions is generally unexpected, and moonlighting enzymes are known in both prokaryotes and eukaryotes. Importantly, this unexpected multi-functionality indicates that caution might be needed on some occasions in interpreting phenotypes that result from the deletion or gene-silencing of some enzymes, including some of the best known enzymes from classic intermediary metabolism. Here, we provide an overview of enzyme moonlighting in parasitic protists. Unequivocal and putative examples of moonlighting are discussed, together with the possibility that the unusual biological characteristics of some parasites either limit opportunities for moonlighting to arise or perhaps contribute to the evolution of novel proteins with clear metabolic ancestry.

Original languageEnglish
Pages (from-to)1467-1475
Number of pages9
JournalParasitology
Volume137
Issue number9
Early online date17 Mar 2010
DOIs
Publication statusPublished - 1 Aug 2010
Externally publishedYes

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