MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

Amanda P. Liggins; Christopher D O Cooper; Charles H. Lawrie; Philip J. Brown; Graham P. Collins; Chris S. Hatton; Karen Pulford; Alison H. Banham

doi:10.1111/j.1365-2141.2007.06680.x

MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

Amanda P. Liggins, Christopher D O Cooper, Charles H. Lawrie, Philip J. Brown, Graham P. Collins, Chris S. Hatton, Karen Pulford, Alison H. Banham

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.

Original language	English
Pages (from-to)	479-486
Number of pages	8
Journal	British Journal of Haematology
Volume	138
Issue number	4
Early online date	29 Jun 2007
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06680.x
Publication status	Published - Aug 2007
Externally published	Yes

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title = "MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas",

abstract = "The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.",

keywords = "Lymphoma, MORC, SEREX, Zinc finger",

author = "Liggins, {Amanda P.} and Cooper, {Christopher D O} and Lawrie, {Charles H.} and Brown, {Philip J.} and Collins, {Graham P.} and Hatton, {Chris S.} and Karen Pulford and Banham, {Alison H.}",

year = "2007",

month = aug,

doi = "10.1111/j.1365-2141.2007.06680.x",

language = "English",

volume = "138",

pages = "479--486",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

AU - Liggins, Amanda P.

AU - Cooper, Christopher D O

AU - Lawrie, Charles H.

AU - Brown, Philip J.

AU - Collins, Graham P.

AU - Hatton, Chris S.

AU - Pulford, Karen

AU - Banham, Alison H.

PY - 2007/8

Y1 - 2007/8

N2 - The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.

AB - The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.

KW - Lymphoma

KW - MORC

KW - SEREX

KW - Zinc finger

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DO - 10.1111/j.1365-2141.2007.06680.x

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ER -

MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

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