Abstract
The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.
| Original language | English |
|---|---|
| Pages (from-to) | 479-486 |
| Number of pages | 8 |
| Journal | British Journal of Haematology |
| Volume | 138 |
| Issue number | 4 |
| Early online date | 29 Jun 2007 |
| DOIs | |
| Publication status | Published - Aug 2007 |
| Externally published | Yes |
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MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. / Liggins, Amanda P.; Cooper, Christopher D O; Lawrie, Charles H.; Brown, Philip J.; Collins, Graham P.; Hatton, Chris S.; Pulford, Karen; Banham, Alison H.
In: British Journal of Haematology, Vol. 138, No. 4, 08.2007, p. 479-486.Research output: Contribution to journal › Article
TY - JOUR
T1 - MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas
AU - Liggins, Amanda P.
AU - Cooper, Christopher D O
AU - Lawrie, Charles H.
AU - Brown, Philip J.
AU - Collins, Graham P.
AU - Hatton, Chris S.
AU - Pulford, Karen
AU - Banham, Alison H.
PY - 2007/8
Y1 - 2007/8
N2 - The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.
AB - The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.
KW - Lymphoma
KW - MORC
KW - SEREX
KW - Zinc finger
UR - http://www.scopus.com/inward/record.url?scp=34447300688&partnerID=8YFLogxK
UR - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2141
U2 - 10.1111/j.1365-2141.2007.06680.x
DO - 10.1111/j.1365-2141.2007.06680.x
M3 - Article
C2 - 17608765
AN - SCOPUS:34447300688
VL - 138
SP - 479
EP - 486
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 4
ER -