MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

Amanda P. Liggins, Christopher D O Cooper, Charles H. Lawrie, Philip J. Brown, Graham P. Collins, Chris S. Hatton, Karen Pulford, Alison H. Banham

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.

LanguageEnglish
Pages479-486
Number of pages8
JournalBritish Journal of Haematology
Volume138
Issue number4
Early online date29 Jun 2007
DOIs
Publication statusPublished - Aug 2007
Externally publishedYes

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Messenger RNA
B-Lymphocytes
Nuclear Matrix
Cell Line
Nuclear Localization Signals
Germinal Center
Zinc Fingers
Hodgkin Disease
Placenta
Antibody Formation
Testis
Lymphoma
Chromosomes
Biomarkers
Antigens
Genes
Proteins

Cite this

Liggins, Amanda P. ; Cooper, Christopher D O ; Lawrie, Charles H. ; Brown, Philip J. ; Collins, Graham P. ; Hatton, Chris S. ; Pulford, Karen ; Banham, Alison H. / MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. In: British Journal of Haematology. 2007 ; Vol. 138, No. 4. pp. 479-486.
@article{5abe964df0e14bed8ea75d5ff733a6bc,
title = "MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas",
abstract = "The OX-TES-4 antigen originally elicited an antibody response in 50{\%} of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66{\%}) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.",
keywords = "Lymphoma, MORC, SEREX, Zinc finger",
author = "Liggins, {Amanda P.} and Cooper, {Christopher D O} and Lawrie, {Charles H.} and Brown, {Philip J.} and Collins, {Graham P.} and Hatton, {Chris S.} and Karen Pulford and Banham, {Alison H.}",
year = "2007",
month = "8",
doi = "10.1111/j.1365-2141.2007.06680.x",
language = "English",
volume = "138",
pages = "479--486",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "4",

}

MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. / Liggins, Amanda P.; Cooper, Christopher D O; Lawrie, Charles H.; Brown, Philip J.; Collins, Graham P.; Hatton, Chris S.; Pulford, Karen; Banham, Alison H.

In: British Journal of Haematology, Vol. 138, No. 4, 08.2007, p. 479-486.

Research output: Contribution to journalArticle

TY - JOUR

T1 - MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas

AU - Liggins, Amanda P.

AU - Cooper, Christopher D O

AU - Lawrie, Charles H.

AU - Brown, Philip J.

AU - Collins, Graham P.

AU - Hatton, Chris S.

AU - Pulford, Karen

AU - Banham, Alison H.

PY - 2007/8

Y1 - 2007/8

N2 - The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.

AB - The OX-TES-4 antigen originally elicited an antibody response in 50% of diffuse large B-cell lymphoma (DLBCL) patients but not in control subjects. OX-TES-4 is encoded by a novel gene, MORC4, located at chromosome Xq22.3. The MORC4 protein contains a HATPase-c domain, CW zinc finger motif, nuclear localisation signals and a nuclear matrix-binding domain, together with a coiled-coil region. MORC4 mRNA is widely expressed at low levels in normal tissues, showing highest expression levels in placenta and testis. mRNA levels were increased in non-germinal centre-derived DLBCL and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells. Nineteen DLBCL patients (66%) expressed significantly higher levels of MORC4 mRNA than normal B cells (P = 0.0031). The differential expression of MORC4 identifies this molecule as a potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of DLBCL patients.

KW - Lymphoma

KW - MORC

KW - SEREX

KW - Zinc finger

UR - http://www.scopus.com/inward/record.url?scp=34447300688&partnerID=8YFLogxK

UR - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2141

U2 - 10.1111/j.1365-2141.2007.06680.x

DO - 10.1111/j.1365-2141.2007.06680.x

M3 - Article

VL - 138

SP - 479

EP - 486

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -