Research output per year
Research output per year
Syed Shahzad Hasan, Toby Capstick, Raees Ahmed, Chia Siang Kow, Faizan Mazhar, Hamid A Merchant, Syed Tabish Razi Zaidi
Research output: Contribution to journal › Review article › peer-review
Objectives: The acute respiratory distress syndrome (ARDS) secondary to viral pneumonitis is one of the main causes of high mortality in patients with COVID-19 (novel coronavirus disease 2019). We systematically reviewed mortality in COVID-19 patients with ARDS and the potential role of systemic corticosteroids in COVID-19 patients. Methods: Electronic databases and country-specific healthcare databases were searched to identify relevant studies/reports. The quality assessment of individual studies was conducted using the Newcastle–Ottawa Scale. Country-specific proportion of individuals with COVID-19 who developed ARDS and reported death were combined in a random-effect meta-analysis to give a pooled mortality estimate of ARDS. Results: The overall pooled mortality estimate among 10,815 ARDS cases in COVID-19 patients was 39% (95% CI: 23–56%). The pooled mortality estimate for China was 69% (95% CI: 67–72%). In Europe, the highest mortality estimate among COVID-19 patients with ARDS was reported in Poland (73%; 95% CI: 58–86%) while Germany had the lowest mortality estimate (13%; 95% CI: 2–29%) among COVID-19 patients with ARDS. The median crude mortality rate of COVID-19 patients with reported corticosteroid use was 28.0% (lower quartile: 13.9%; upper quartile: 53.6%). Conclusions: The high mortality in COVID-19 associated ARDS necessitates a prompt and aggressive treatment strategy which includes corticosteroids. Most of the studies included no information on the dosing regimen of corticosteroid therapy, however, low-dose corticosteroid therapy or pulse corticosteroid therapy appears to have a beneficial role in the management of severely ill COVID-19 patients.
Original language | English |
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Pages (from-to) | 1149-1163 |
Number of pages | 15 |
Journal | Expert Review of Respiratory Medicine |
Volume | 14 |
Issue number | 11 |
Early online date | 31 Jul 2020 |
DOIs | |
Publication status | Published - 1 Nov 2020 |
Person: Academic
Research output: Contribution to journal › Comment/debate › peer-review
Research output: Contribution to journal › Article › peer-review
Hamid Merchant
5/09/21
1 Media contribution
Press/Media: Research
Hamid Merchant
29/01/21 → 13/02/21
2 Media contributions
Press/Media: Expert Comment
Hamid Merchant
23/12/20
1 Media contribution
Press/Media: Expert Comment
Syed Shahzad Hasan & Hamid Merchant
25/11/20 → 26/11/20
2 items of Media coverage
Press/Media: Research