New developments in the synthesis of (e)-8-styrylflavones

Orlando D.C.C. De Azevedo, Raquel S.G.R. Seixas, Artur M.S. Silva

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization-iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.

Original languageEnglish
Pages (from-to)1379-1384
Number of pages6
Issue number10
Early online date4 May 2015
Publication statusPublished - 16 Jun 2015
Externally publishedYes


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