New developments in the synthesis of (e)-8-styrylflavones

Orlando D.C.C. De Azevedo; Raquel S.G.R. Seixas; Artur M.S. Silva

doi:10.1055/s-0034-1380208

New developments in the synthesis of (e)-8-styrylflavones

Orlando D.C.C. De Azevedo, Raquel S.G.R. Seixas, Artur M.S. Silva

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization-iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.

Original language	English
Pages (from-to)	1379-1384
Number of pages	6
Journal	Synlett
Volume	26
Issue number	10
Early online date	4 May 2015
DOIs	https://doi.org/10.1055/s-0034-1380208
Publication status	Published - 16 Jun 2015
Externally published	Yes

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title = "New developments in the synthesis of (e)-8-styrylflavones",

abstract = "A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization-iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.",

keywords = "cyclodehydrogenation, Heck reaction, iodoflavones, palladium, styrylflavones",

author = "\{De Azevedo\}, \{Orlando D.C.C.\} and Seixas, \{Raquel S.G.R.\} and Silva, \{Artur M.S.\}",

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AU - De Azevedo, Orlando D.C.C.

AU - Seixas, Raquel S.G.R.

AU - Silva, Artur M.S.

PY - 2015/6/16

Y1 - 2015/6/16

N2 - A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization-iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.

AB - A novel route for the synthesis of new (E)-8-styrylflavones is reported. This methodology involves the regio- and stereoselective Heck cross-coupling reaction of 8-iodoflavones and styrene derivatives. The Heck precursors, 8-iodoflavones, were obtained through an efficient regioselective one-pot oxidative cyclization-iodination reaction of (E)-2′-hydroxychalcones by applying the iodine/dimethyl sulfoxide system.

KW - cyclodehydrogenation

KW - Heck reaction

KW - iodoflavones

KW - palladium

KW - styrylflavones

UR - https://www.scopus.com/pages/publications/84930376545

U2 - 10.1055/s-0034-1380208

DO - 10.1055/s-0034-1380208

M3 - Article

AN - SCOPUS:84930376545

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VL - 26

SP - 1379

EP - 1384

JO - Synlett

JF - Synlett

IS - 10

ER -

New developments in the synthesis of (e)-8-styrylflavones

Abstract

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