New strategies for preoperative skin antisepsis

Miriam Ulmer, Juergen Lademann, Alexa Patzelt, Fanny Knorr, Axel Kramer, Torsten Koburger, Ojan Assadian, Georg Daeschlein, Bernhard Lange-Asschenfeldt

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

During the past decades, encouraging progress has been made in the prevention of surgical site infections (SSI). However, as SSI still occur today, strategic prevention measures such as standardized skin antisepsis must be implemented and rigorously promoted. Recent discoveries in skin physiology necessitate the development of novel antiseptic agents and procedures in order to ameliorate their efficacy. In particular, alternate target structures in the skin need to be taken into consideration for the development of the next generation of antiseptics. Recent investigations have shown that a high number of microorganisms are located within and in the close vicinity of the hair follicles. This suggests that these structures are an important reservoir of bacterial growth and activity in human skin. To date, it has not been fully elucidated to what extent conventional liquid antiseptics sufficiently target the hair follicle-related microbial population. Modern technologies such as tissue-tolerable plasma (TTP) have been tested for their potential antiseptic efficiency by reducing the bacterial load in the skin and in the hair follicles. First experiments using liposomes to deliver antiseptics into the hair follicles have been evaluated for their potential clinical application. The present review evaluates these two innovative methods for their efficacy and applicability in preoperative skin antiseptics.

Original languageEnglish
Pages (from-to)283-292
Number of pages10
JournalSkin Pharmacology and Physiology
Volume27
Issue number6
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Fingerprint

Antisepsis
Local Anti-Infective Agents
Hair Follicle
Skin
Surgical Wound Infection
Skin Physiological Phenomena
Bacterial Load
Human Activities
Liposomes
Technology
Growth
Population

Cite this

Ulmer, M., Lademann, J., Patzelt, A., Knorr, F., Kramer, A., Koburger, T., ... Lange-Asschenfeldt, B. (2014). New strategies for preoperative skin antisepsis. Skin Pharmacology and Physiology, 27(6), 283-292. https://doi.org/10.1159/000357387
Ulmer, Miriam ; Lademann, Juergen ; Patzelt, Alexa ; Knorr, Fanny ; Kramer, Axel ; Koburger, Torsten ; Assadian, Ojan ; Daeschlein, Georg ; Lange-Asschenfeldt, Bernhard. / New strategies for preoperative skin antisepsis. In: Skin Pharmacology and Physiology. 2014 ; Vol. 27, No. 6. pp. 283-292.
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Ulmer, M, Lademann, J, Patzelt, A, Knorr, F, Kramer, A, Koburger, T, Assadian, O, Daeschlein, G & Lange-Asschenfeldt, B 2014, 'New strategies for preoperative skin antisepsis', Skin Pharmacology and Physiology, vol. 27, no. 6, pp. 283-292. https://doi.org/10.1159/000357387

New strategies for preoperative skin antisepsis. / Ulmer, Miriam; Lademann, Juergen; Patzelt, Alexa; Knorr, Fanny; Kramer, Axel; Koburger, Torsten; Assadian, Ojan; Daeschlein, Georg; Lange-Asschenfeldt, Bernhard.

In: Skin Pharmacology and Physiology, Vol. 27, No. 6, 07.2014, p. 283-292.

Research output: Contribution to journalReview article

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T1 - New strategies for preoperative skin antisepsis

AU - Ulmer, Miriam

AU - Lademann, Juergen

AU - Patzelt, Alexa

AU - Knorr, Fanny

AU - Kramer, Axel

AU - Koburger, Torsten

AU - Assadian, Ojan

AU - Daeschlein, Georg

AU - Lange-Asschenfeldt, Bernhard

PY - 2014/7

Y1 - 2014/7

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U2 - 10.1159/000357387

DO - 10.1159/000357387

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VL - 27

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JO - Skin Pharmacology and Physiology

JF - Skin Pharmacology and Physiology

SN - 1660-5527

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Ulmer M, Lademann J, Patzelt A, Knorr F, Kramer A, Koburger T et al. New strategies for preoperative skin antisepsis. Skin Pharmacology and Physiology. 2014 Jul;27(6):283-292. https://doi.org/10.1159/000357387