Niche metabolism in parasitic protozoa

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Complete or partial genome sequences have recently become available for several medically and evolutionarily important parasitic protozoa. Through the application of bioinformatics complete metabolic repertoires for these parasites can be predicted. For experimentally intractable parasites insight provided by metabolic maps generated in silico has been startling. At its more extreme end, such bioinformatics reckoning facilitated the discovery in some parasites of mitochondria remodelled beyond previous recognition, and the identification of a non-photosynthetic chloroplast relic in malarial parasites. However, for experimentally tractable parasites, mapping of the general metabolic terrain is only a first step in understanding how the parasite modulates its streamlined, yet still often puzzlingly complex, metabolism in order to complete life cycles within host, vector, or environment. This review provides a comparative overview and discussion of metabolic strategies used by several different parasitic protozoa in order to subvert and survive host defences, and illustrates how genomic data contribute to the elucidation of parasite metabolism.

Original languageEnglish
Pages (from-to)101-118
Number of pages18
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume361
Issue number1465
DOIs
Publication statusPublished - 29 Jan 2006
Externally publishedYes

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