No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Luísa Pereira; João Gonçalves; Ricardo Franco-Duarte; Júlia Silva; Tiago Rocha; Christiane Arnold; Martin Richards; Vincent Macaulay

doi:10.1093/molbev/msm004

No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Luísa Pereira, João Gonçalves, Ricardo Franco-Duarte, Júlia Silva, Tiago Rocha, Christiane Arnold, Martin Richards, Vincent Macaulay

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The first complete mitochondrial DNA (mtDNA) sequences (∼16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

Original language	English
Pages (from-to)	868-874
Number of pages	7
Journal	Molecular Biology and Evolution
Volume	24
Issue number	3
Early online date	11 Jan 2007
DOIs	https://doi.org/10.1093/molbev/msm004
Publication status	Published - 1 Mar 2007
Externally published	Yes

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title = "No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males",

abstract = "The first complete mitochondrial DNA (mtDNA) sequences (∼16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.",

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AU - Gonçalves, João

AU - Franco-Duarte, Ricardo

AU - Silva, Júlia

AU - Rocha, Tiago

AU - Arnold, Christiane

AU - Richards, Martin

AU - Macaulay, Vincent

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N2 - The first complete mitochondrial DNA (mtDNA) sequences (∼16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

AB - The first complete mitochondrial DNA (mtDNA) sequences (∼16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

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No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Abstract

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