No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males

Luísa Pereira, João Gonçalves, Ricardo Franco-Duarte, Júlia Silva, Tiago Rocha, Christiane Arnold, Martin Richards, Vincent Macaulay

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Abstract

The first complete mitochondrial DNA (mtDNA) sequences (∼16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male fertility, once supported by haplogroup association studies based on the screening of hypervariable region I. The hypothesis of maternally driven selection acting in male reproductive success must thus be treated with caution.

Original languageEnglish
Pages (from-to)868-874
Number of pages7
JournalMolecular Biology and Evolution
Volume24
Issue number3
Early online date11 Jan 2007
DOIs
Publication statusPublished - 1 Mar 2007
Externally publishedYes

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Pereira, L., Gonçalves, J., Franco-Duarte, R., Silva, J., Rocha, T., Arnold, C., ... Macaulay, V. (2007). No Evidence for an mtDNA Role in Sperm Motility: Data from Complete Sequencing of Asthenozoospermic Males. Molecular Biology and Evolution, 24(3), 868-874. https://doi.org/10.1093/molbev/msm004