Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action

Whilst there have been some significant improvements in treatments and patient outcomes for some cancers, for other cancers there has been little change in survival rates for many years. Side effects resulting from the toxicity of agents towards normal cells and tissues and the development of drug resistance continue to limit the effectiveness of traditional and molecular-targeted anti-cancer agents. Other challenges include pharmacokinetics (PK) and delivering sufficient amounts of the active drug to tumour cells in vivo. There is an ongoing need for new anti-cancer agents with novel mechanism(s) of action and the identification of new putative cellular targets and therapeutic strategies that are both potent and selective towards cancer cells.