Abstract
β-Sultams are the sulfonyl analogues of β-lactams and N-acyl β-sultams are novel inactivators of the class C β-lactamase of Enterobacter cloacae P99. The rates of inactivation show a similar pH-rate dependence as that exhibited by the β-lactam antibiotics and with ESIMS data it is suggested that β-sultams sulfonylate the active site serine residue to form a sulfonate ester.
β-Sultams inactivate a class C β-lactamase by sulfonylation of the active site serine.
β-Sultams inactivate a class C β-lactamase by sulfonylation of the active site serine.
Original language | English |
---|---|
Pages (from-to) | 4489-4492 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 13 |
Issue number | 24 |
DOIs | |
Publication status | Published - 15 Dec 2003 |