Abstract
β-Sultams are the sulfonyl analogues of β-lactams and N-acyl β-sultams are novel inactivators of the class C β-lactamase of Enterobacter cloacae P99. The rates of inactivation show a similar pH-rate dependence as that exhibited by the β-lactam antibiotics and with ESIMS data it is suggested that β-sultams sulfonylate the active site serine residue to form a sulfonate ester.
β-Sultams inactivate a class C β-lactamase by sulfonylation of the active site serine.
β-Sultams inactivate a class C β-lactamase by sulfonylation of the active site serine.
| Original language | English |
|---|---|
| Pages (from-to) | 4489-4492 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 13 |
| Issue number | 24 |
| DOIs | |
| Publication status | Published - 15 Dec 2003 |
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Page, M. I., Hinchliffe, P. S., Wood, J. M., Harding, L. P., & Laws, A. P. (2003). Novel mechanism of inhibiting β-Lactamases by sulfonylation using β-Sultams. Bioorganic and Medicinal Chemistry Letters, 13(24), 4489-4492. https://doi.org/10.1016/j.bmcl.2003.08.082