Octenidine dihydrochloride: Chemical characteristics and antimicrobial properties

Ojan Assadian

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The empiric use of antibiotics is being restricted due to the spread of antimicrobial resistance. However, topical antiseptics are less likely to induce resistance, owing to their unspecific mode of action and the high concentrations in which they can be used. One such antiseptic, octenidine dihydrochloride (OCT), can be used either prophylactically or therapeutically on the skin, mucosa and wounds. Evidence to support its use comes from in-vitro, animal and clinical studies on its safety, tolerability and efficacy. This article summarises the physical, chemical and antimicrobial properties of OCT in the context of wound care.

LanguageEnglish
PagesS3-6
JournalJournal of wound care
Volume25
Publication statusPublished - 1 Mar 2016

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octenidine
Local Anti-Infective Agents
Wounds and Injuries
Mucous Membrane
Anti-Bacterial Agents
Safety
Skin

Cite this

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title = "Octenidine dihydrochloride: Chemical characteristics and antimicrobial properties",
abstract = "The empiric use of antibiotics is being restricted due to the spread of antimicrobial resistance. However, topical antiseptics are less likely to induce resistance, owing to their unspecific mode of action and the high concentrations in which they can be used. One such antiseptic, octenidine dihydrochloride (OCT), can be used either prophylactically or therapeutically on the skin, mucosa and wounds. Evidence to support its use comes from in-vitro, animal and clinical studies on its safety, tolerability and efficacy. This article summarises the physical, chemical and antimicrobial properties of OCT in the context of wound care.",
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Octenidine dihydrochloride : Chemical characteristics and antimicrobial properties. / Assadian, Ojan.

In: Journal of wound care, Vol. 25, 01.03.2016, p. S3-6.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Octenidine dihydrochloride

T2 - Journal of wound care

AU - Assadian, Ojan

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The empiric use of antibiotics is being restricted due to the spread of antimicrobial resistance. However, topical antiseptics are less likely to induce resistance, owing to their unspecific mode of action and the high concentrations in which they can be used. One such antiseptic, octenidine dihydrochloride (OCT), can be used either prophylactically or therapeutically on the skin, mucosa and wounds. Evidence to support its use comes from in-vitro, animal and clinical studies on its safety, tolerability and efficacy. This article summarises the physical, chemical and antimicrobial properties of OCT in the context of wound care.

AB - The empiric use of antibiotics is being restricted due to the spread of antimicrobial resistance. However, topical antiseptics are less likely to induce resistance, owing to their unspecific mode of action and the high concentrations in which they can be used. One such antiseptic, octenidine dihydrochloride (OCT), can be used either prophylactically or therapeutically on the skin, mucosa and wounds. Evidence to support its use comes from in-vitro, animal and clinical studies on its safety, tolerability and efficacy. This article summarises the physical, chemical and antimicrobial properties of OCT in the context of wound care.

KW - Antimicrobial efficacy

KW - Biocompatibility index

KW - Biofilm

KW - Contraindications

KW - Cytotoxicity

KW - Octenidine dihydrochloride

KW - Wound antisepsis

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M3 - Article

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SP - S3-6

JO - Journal of wound care

JF - Journal of wound care

SN - 0969-0700

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