On the preparation of ortho-trifluoromethyl phenyl triflate

Duncan Gill, Alison J. Hester, Guy C. Lloyd-Jones

Research output: Contribution to journalReview article

Abstract

In contrast to an earlier report advocating a copper-mediated trifluoromethylation of ortho-iodophenyl triflate, ortho-trifluoromethyl phenyl triflate may be prepared simply by reacting the corresponding phenol with triflic anhydride in the presence of a nucleophilic catalyst and stoichiometric base.

LanguageEnglish
Pages2547-2548
Number of pages2
JournalOrganic and Biomolecular Chemistry
Volume2
Issue number17
Early online date4 Aug 2004
DOIs
Publication statusPublished - 7 Sep 2004
Externally publishedYes

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anhydrides
Phenol
phenols
Copper
catalysts
copper
preparation
Catalysts
triflic anhydride
ortho-trifluoromethyl phenyl triflate

Cite this

Gill, Duncan ; Hester, Alison J. ; Lloyd-Jones, Guy C. / On the preparation of ortho-trifluoromethyl phenyl triflate. In: Organic and Biomolecular Chemistry. 2004 ; Vol. 2, No. 17. pp. 2547-2548.
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On the preparation of ortho-trifluoromethyl phenyl triflate. / Gill, Duncan; Hester, Alison J.; Lloyd-Jones, Guy C.

In: Organic and Biomolecular Chemistry, Vol. 2, No. 17, 07.09.2004, p. 2547-2548.

Research output: Contribution to journalReview article

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AU - Hester, Alison J.

AU - Lloyd-Jones, Guy C.

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AB - In contrast to an earlier report advocating a copper-mediated trifluoromethylation of ortho-iodophenyl triflate, ortho-trifluoromethyl phenyl triflate may be prepared simply by reacting the corresponding phenol with triflic anhydride in the presence of a nucleophilic catalyst and stoichiometric base.

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