In contrast to an earlier report advocating a copper-mediated trifluoromethylation of ortho-iodophenyl triflate, ortho-trifluoromethyl phenyl triflate may be prepared simply by reacting the corresponding phenol with triflic anhydride in the presence of a nucleophilic catalyst and stoichiometric base.
|Number of pages||2|
|Journal||Organic and Biomolecular Chemistry|
|Early online date||4 Aug 2004|
|Publication status||Published - 7 Sep 2004|