@inbook{efea38c367bc4742a722aae46eca6406,
title = "Oncolytic Viruses and Cell Migration",
abstract = "Viruses have always accompanied human life and impacted our health. Recent developments in the medical field have highlighted that it is possible to exploit the requirement of a virus to replicate within a host cell. For example, viruses can be genetically engineered to specifically target, enter and finally destroy tumour cells. These viruses are called oncolytic viruses (OVs). In addition, it has been discovered that OV infections can also affect cell migration by utilizing the host cell{\textquoteright}s microtubule cytoskeleton to reach replication sites within the cell. Consequently, finely tuned microtubule dynamics are disturbed, with follow-on effects on cell migration. This chapter will provide a general background on viruses and their life cycle, OVs, viral interaction with the microtubules and their effect on cell migration. Specific examples of these interactions are given, and migration assays that include the use of viruses are described. The newest developments in the field are summarized.",
keywords = "Cell migration, Oncolytic virus, tumour",
author = "Anke Bruning-Richardson",
year = "2024",
month = nov,
day = "13",
doi = "10.1007/978-3-031-64532-7_13",
language = "English",
isbn = "9783031645310",
series = "Learning Materials in Biosciences",
publisher = "Springer, Cham",
pages = "277--298",
editor = "Anke Br{\"u}ning-Richardson and Sabine Knipp",
booktitle = "Cell Migration in Development, Health and Disease",
address = "Switzerland",
}
