Purpose: To identify and rank opportunities and challenges around adapting supported employment interventions for people with chronic low back pain.Methods: Delegates from an international back and neck research forum were invited to join an expert panel. A modified nominal group technique was used with four stages: silent generation, round robin, clarification, and ranking. Ranked items were reported back and ratified by the panel.Results: Nine experienced researchers working in fields related to low back pain and disability joined the panel. Forty-eight items were generated and grouped into 12 categories of opportunities/challenges. Categories ranked most important related respectively to policy and legislation, ensuring operational integration across different systems, funding interventions, and managing attitudes towards work and health, workplace flexibility,availability of ‘good’ work for this client group, dissonance between client and system aims,timing of interventions, and intervention development.Conclusion: An expert panel believes the most important opportunities/challenges around adapting supporting employment interventions for people with chronic low back pain are facilitating integration/communication between systems and institutions providing intervention components, optimising research outputs for informing policy needs, and encouraging discussion around funding mechanisms for research and interventions.Addressing these factors may help improve the quality and impact of future interventions.