Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

Zenghai Lu; Joseph Boadi; Simon Danby; Mike Cork; Stephen J. Matcher

doi:10.1117/12.2006104

Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

Zenghai Lu, Joseph Boadi, Simon Danby, Mike Cork, Stephen J. Matcher

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In one of 4 subjects we found evidence that the epidermis was actually thickened following treatment using Tacrolimus.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics IX
Editors	Andreas Mandelis, Brian Jet-Fei Wong, Justus F. Ilgner M.D., Anita Mahadevan-Jansen, E. Duco Jansen, Henry Hirschberg M.D., Steen J. Madsen, Hyun Wook Kang, Bodo E. Knudsen M.D., Nikiforos Kollias, Bernard Choi, Haishan Zeng, Melissa J. Suter, Stephen Lam, Matthew Brenner, Kenton W. Gregory M.D., Guillermo J. Tearney M.D., Laura Marcu
Publisher	SPIE
Number of pages	7
Volume	8565
ISBN (Print)	9780819493347
DOIs	https://doi.org/10.1117/12.2006104
Publication status	Published - 8 Mar 2013
Externally published	Yes
Event	Photonic Therapeutics and Diagnostics IX - San Francisco, United States Duration: 2 Feb 2013 → 7 Feb 2013 Conference number: 9

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	8565
ISSN (Print)	1605-7422

Conference

Conference	Photonic Therapeutics and Diagnostics IX
Country/Territory	United States
City	San Francisco
Period	2/02/13 → 7/02/13

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Lu, Z., Boadi, J., Danby, S., Cork, M., & Matcher, S. J. (2013). Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. In A. Mandelis, B. J-F. Wong, J. F. Ilgner M.D., A. Mahadevan-Jansen, E. Duco Jansen, H. Hirschberg M.D., S. J. Madsen, H. Wook Kang, B. E. Knudsen M.D., N. Kollias, B. Choi, H. Zeng, M. J. Suter, S. Lam, M. Brenner, K. W. Gregory M.D., G. J. Tearney M.D., & L. Marcu (Eds.), Photonic Therapeutics and Diagnostics IX (Vol. 8565). [85650C] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8565). SPIE. https://doi.org/10.1117/12.2006104

Lu, Zenghai ; Boadi, Joseph ; Danby, Simon et al. / Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. Photonic Therapeutics and Diagnostics IX. editor / Andreas Mandelis ; Brian Jet-Fei Wong ; Justus F. Ilgner M.D. ; Anita Mahadevan-Jansen ; E. Duco Jansen ; Henry Hirschberg M.D. ; Steen J. Madsen ; Hyun Wook Kang ; Bodo E. Knudsen M.D. ; Nikiforos Kollias ; Bernard Choi ; Haishan Zeng ; Melissa J. Suter ; Stephen Lam ; Matthew Brenner ; Kenton W. Gregory M.D. ; Guillermo J. Tearney M.D. ; Laura Marcu. Vol. 8565 SPIE, 2013. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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title = "Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative",

abstract = "The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In one of 4 subjects we found evidence that the epidermis was actually thickened following treatment using Tacrolimus.",

keywords = "Betamethasone valerate, Epidermal atrophy, Epidermis, Non-steroidal anti-inflammatory drugs, Optical coherence tomography, Tacrolimus monohydrate, Topical corticosteroids, Skin, Image resolution, Backscatter, Collagen, Confocal microscopy, Diagnostics, Reflectivity, Dermatology, Pathogens",

author = "Zenghai Lu and Joseph Boadi and Simon Danby and Mike Cork and Matcher, {Stephen J.}",

year = "2013",

month = mar,

day = "8",

doi = "10.1117/12.2006104",

language = "English",

isbn = "9780819493347",

volume = "8565",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Andreas Mandelis and Wong, {Brian Jet-Fei} and {Ilgner M.D.}, {Justus F.} and Anita Mahadevan-Jansen and {Duco Jansen}, {E. } and {Hirschberg M.D.}, Henry and Madsen, {Steen J.} and {Wook Kang}, Hyun and {Knudsen M.D.}, {Bodo E.} and Nikiforos Kollias and Bernard Choi and Haishan Zeng and Suter, {Melissa J.} and Stephen Lam and Matthew Brenner and {Gregory M.D.}, {Kenton W.} and {Tearney M.D.}, {Guillermo J.} and Laura Marcu",

booktitle = "Photonic Therapeutics and Diagnostics IX",

address = "United States",

note = "Photonic Therapeutics and Diagnostics IX ; Conference date: 02-02-2013 Through 07-02-2013",

}

Lu, Z, Boadi, J, Danby, S, Cork, M & Matcher, SJ 2013, Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. in A Mandelis, BJ-F Wong, JF Ilgner M.D., A Mahadevan-Jansen, E Duco Jansen, H Hirschberg M.D., SJ Madsen, H Wook Kang, BE Knudsen M.D., N Kollias, B Choi, H Zeng, MJ Suter, S Lam, M Brenner, KW Gregory M.D., GJ Tearney M.D. & L Marcu (eds), Photonic Therapeutics and Diagnostics IX. vol. 8565, 85650C, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8565, SPIE, Photonic Therapeutics and Diagnostics IX, San Francisco, California, United States, 2/02/13. https://doi.org/10.1117/12.2006104

Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. / Lu, Zenghai; Boadi, Joseph; Danby, Simon et al.

Photonic Therapeutics and Diagnostics IX. ed. / Andreas Mandelis; Brian Jet-Fei Wong; Justus F. Ilgner M.D.; Anita Mahadevan-Jansen; E. Duco Jansen; Henry Hirschberg M.D.; Steen J. Madsen; Hyun Wook Kang; Bodo E. Knudsen M.D.; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Melissa J. Suter; Stephen Lam; Matthew Brenner; Kenton W. Gregory M.D.; Guillermo J. Tearney M.D.; Laura Marcu. Vol. 8565 SPIE, 2013. 85650C (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8565).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

AU - Lu, Zenghai

AU - Boadi, Joseph

AU - Danby, Simon

AU - Cork, Mike

AU - Matcher, Stephen J.

N1 - Conference code: 9

PY - 2013/3/8

Y1 - 2013/3/8

N2 - The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In one of 4 subjects we found evidence that the epidermis was actually thickened following treatment using Tacrolimus.

AB - The effects on skin of two commercially available topical creams for the treatment of eczema are quantitatively studied using optical coherence tomography. An archetypal corticosteroid (Betamethasone valerate) is compared with a nonsteroidal anti-inflammatory drug (Tacrolimus monohydrate) via left/right comparisons of the epidermal thickness of volar forearm skin on selected volunteers, at baseline and after 14 days of treatment. In 3 of 4 subjects we confirmed previous observations that corticosteroids produce pronounced physical thinning of the epidermis over timescales of a few weeks. In 3 of 4 subjects we further found that Tacrolimus produced no change in epidermal thickness. In one of 4 subjects we found evidence that the epidermis was actually thickened following treatment using Tacrolimus.

KW - Betamethasone valerate

KW - Epidermal atrophy

KW - Epidermis

KW - Non-steroidal anti-inflammatory drugs

KW - Optical coherence tomography

KW - Tacrolimus monohydrate

KW - Topical corticosteroids

KW - Skin

KW - Image resolution

KW - Backscatter

KW - Collagen

KW - Confocal microscopy

KW - Diagnostics

KW - Reflectivity

KW - Dermatology

KW - Pathogens

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U2 - 10.1117/12.2006104

DO - 10.1117/12.2006104

M3 - Conference contribution

AN - SCOPUS:84878185283

SN - 9780819493347

VL - 8565

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photonic Therapeutics and Diagnostics IX

A2 - Mandelis, Andreas

A2 - Wong, Brian Jet-Fei

A2 - Ilgner M.D., Justus F.

A2 - Mahadevan-Jansen, Anita

A2 - Duco Jansen, E.

A2 - Hirschberg M.D., Henry

A2 - Madsen, Steen J.

A2 - Wook Kang, Hyun

A2 - Knudsen M.D., Bodo E.

A2 - Kollias, Nikiforos

A2 - Choi, Bernard

A2 - Zeng, Haishan

A2 - Suter, Melissa J.

A2 - Lam, Stephen

A2 - Brenner, Matthew

A2 - Gregory M.D., Kenton W.

A2 - Tearney M.D., Guillermo J.

A2 - Marcu, Laura

PB - SPIE

T2 - Photonic Therapeutics and Diagnostics IX

Y2 - 2 February 2013 through 7 February 2013

ER -

Lu Z, Boadi J, Danby S, Cork M, Matcher SJ. Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. In Mandelis A, Wong BJ-F, Ilgner M.D. JF, Mahadevan-Jansen A, Duco Jansen E, Hirschberg M.D. H, Madsen SJ, Wook Kang H, Knudsen M.D. BE, Kollias N, Choi B, Zeng H, Suter MJ, Lam S, Brenner M, Gregory M.D. KW, Tearney M.D. GJ, Marcu L, editors, Photonic Therapeutics and Diagnostics IX. Vol. 8565. SPIE. 2013. 85650C. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2006104

Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative

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