Turnouts are a key element of the railway system. They are also the part of the system with the highest number of degradation modes and associated failures. There are a number of reasons for this, including high dynamic loads resulting from non-uniform rail geometry and track support stiffness. The main aim of this study is to propose a methodology to optimise the pad stiffness along a crossing panel in order to achieve a decrease in the indicators of the most common failure modes. A three-dimensional vehicle/track interaction model has been established, considering a detailed description of the crossing panel support structure. A genetic algorithm has been applied to two main types of constructions, namely direct and indirect fixing, to find the optimum combinations of resilient pad characteristics for various cases of travelling direction, travelling speed and support conditions.