Oral Solid Dosage Forms

Oral drug delivery remains the most popular and convenient way of administering drugs in comparison with the other routes. Advantages include their effectiveness, convenience, less expensive, and non-invasiveness. Most of the conventional oral dosage forms, such as tablets and capsules, are formulated to deliver the active pharmaceutical ingredient (API) shortly following intake. This chapter discusses various oral solid dosage forms, their manufacturing, and factors that affect their drug release. The manufacture of safe and effective medications is a major challenge in the pharmaceutical field as such this chapter also discusses the regulatory considerations around oral solid dosage form developments which includes components of the drug product (P.2.1), formulation development (P.2.2), and manufacturing process development (P.2.3). Finally, computational approaches with regard to formulation designs, process developments, and quality by digital design (QbDD) are discussed in relation to the development of these formulations.