Origin and spread of human mitochondrial DNA haplogroup U7

Hovhannes Sahakyan, Baharak Hooshiar Kashani, Rakesh Tamang, Alena Kushniarevich, Amirtharaj Francis, Marta D. Costa, Ajai Kumar Pathak, Zaruhi Khachatryan, Indu Sharma, Mannis Van Oven, Jüri Parik, Hrant Hovhannisyan, Ene Metspalu, Erwan Pennarun, Monika Karmin, Erika Tamm, Kristiina Tambets, Ardeshir Bahmanimehr, Tuuli Reisberg, Maere Reidla & 59 others Alessandro Achilli, Anna Olivieri, Francesca Gandini, Ugo A. Perego, Nadia Al-Zahery, Massoud Houshmand, Mohammad Hossein Sanati, Pedro Soares, Ekta Rai, Jelena Šarac, Tena Šarić, Varun Sharma, Luisa Pereira, Veronica Fernandes, Viktor Černý, Shirin Farjadian, Deepankar Pratap Singh, Hülya Azakli, Duran Üstek, Natalia Ekomasova Trofimova, Ildus Kutuev, Sergei Litvinov, Marina Bermisheva, Elza K. Khusnutdinova, Niraj Rai, Manvendra Singh, Vijay Kumar Singh, Alla G. Reddy, Helle Viivi Tolk, Svjetlana Cvjetan, Lovorka Barac Lauc, Pavao Rudan, Emmanuel N. Michalodimitrakis, Nicholas P. Anagnou, Kalliopi I. Pappa, Maria V. Golubenko, Vladimir Orekhov, Svetlana A. Borinskaya, Katrin Kaldma, Monica A. Schauer, Maya Simionescu, Vladislava Gusar, Elena Grechanina, Periyasamy Govindaraj, Mikhail Voevoda, Larissa Damba, Swarkar Sharma, Lalji Singh, Ornella Semino, Doron M. Behar, Levon Yepiskoposyan, Martin B. Richards, Mait Metspalu, Toomas Kivisild, Kumarasamy Thangaraj, Phillip Endicott, Gyaneshwer Chaubey, Antonio Torroni, Richard Villems

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

Original languageEnglish
Article number46044
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 7 Apr 2017

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mitochondrial DNA
hunter-gatherer
Bronze Age
coalescence
steppe
Europe
Holocene
Pleistocene
Asia

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Sahakyan, H., Kashani, B. H., Tamang, R., Kushniarevich, A., Francis, A., Costa, M. D., ... Villems, R. (2017). Origin and spread of human mitochondrial DNA haplogroup U7. Scientific Reports, 7, [46044]. https://doi.org/10.1038/srep46044
Sahakyan, Hovhannes ; Kashani, Baharak Hooshiar ; Tamang, Rakesh ; Kushniarevich, Alena ; Francis, Amirtharaj ; Costa, Marta D. ; Pathak, Ajai Kumar ; Khachatryan, Zaruhi ; Sharma, Indu ; Van Oven, Mannis ; Parik, Jüri ; Hovhannisyan, Hrant ; Metspalu, Ene ; Pennarun, Erwan ; Karmin, Monika ; Tamm, Erika ; Tambets, Kristiina ; Bahmanimehr, Ardeshir ; Reisberg, Tuuli ; Reidla, Maere ; Achilli, Alessandro ; Olivieri, Anna ; Gandini, Francesca ; Perego, Ugo A. ; Al-Zahery, Nadia ; Houshmand, Massoud ; Sanati, Mohammad Hossein ; Soares, Pedro ; Rai, Ekta ; Šarac, Jelena ; Šarić, Tena ; Sharma, Varun ; Pereira, Luisa ; Fernandes, Veronica ; Černý, Viktor ; Farjadian, Shirin ; Singh, Deepankar Pratap ; Azakli, Hülya ; Üstek, Duran ; Trofimova, Natalia Ekomasova ; Kutuev, Ildus ; Litvinov, Sergei ; Bermisheva, Marina ; Khusnutdinova, Elza K. ; Rai, Niraj ; Singh, Manvendra ; Singh, Vijay Kumar ; Reddy, Alla G. ; Tolk, Helle Viivi ; Cvjetan, Svjetlana ; Lauc, Lovorka Barac ; Rudan, Pavao ; Michalodimitrakis, Emmanuel N. ; Anagnou, Nicholas P. ; Pappa, Kalliopi I. ; Golubenko, Maria V. ; Orekhov, Vladimir ; Borinskaya, Svetlana A. ; Kaldma, Katrin ; Schauer, Monica A. ; Simionescu, Maya ; Gusar, Vladislava ; Grechanina, Elena ; Govindaraj, Periyasamy ; Voevoda, Mikhail ; Damba, Larissa ; Sharma, Swarkar ; Singh, Lalji ; Semino, Ornella ; Behar, Doron M. ; Yepiskoposyan, Levon ; Richards, Martin B. ; Metspalu, Mait ; Kivisild, Toomas ; Thangaraj, Kumarasamy ; Endicott, Phillip ; Chaubey, Gyaneshwer ; Torroni, Antonio ; Villems, Richard. / Origin and spread of human mitochondrial DNA haplogroup U7. In: Scientific Reports. 2017 ; Vol. 7.
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title = "Origin and spread of human mitochondrial DNA haplogroup U7",
abstract = "Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.",
author = "Hovhannes Sahakyan and Kashani, {Baharak Hooshiar} and Rakesh Tamang and Alena Kushniarevich and Amirtharaj Francis and Costa, {Marta D.} and Pathak, {Ajai Kumar} and Zaruhi Khachatryan and Indu Sharma and {Van Oven}, Mannis and J{\"u}ri Parik and Hrant Hovhannisyan and Ene Metspalu and Erwan Pennarun and Monika Karmin and Erika Tamm and Kristiina Tambets and Ardeshir Bahmanimehr and Tuuli Reisberg and Maere Reidla and Alessandro Achilli and Anna Olivieri and Francesca Gandini and Perego, {Ugo A.} and Nadia Al-Zahery and Massoud Houshmand and Sanati, {Mohammad Hossein} and Pedro Soares and Ekta Rai and Jelena Šarac and Tena Šarić and Varun Sharma and Luisa Pereira and Veronica Fernandes and Viktor Čern{\'y} and Shirin Farjadian and Singh, {Deepankar Pratap} and H{\"u}lya Azakli and Duran {\"U}stek and Trofimova, {Natalia Ekomasova} and Ildus Kutuev and Sergei Litvinov and Marina Bermisheva and Khusnutdinova, {Elza K.} and Niraj Rai and Manvendra Singh and Singh, {Vijay Kumar} and Reddy, {Alla G.} and Tolk, {Helle Viivi} and Svjetlana Cvjetan and Lauc, {Lovorka Barac} and Pavao Rudan and Michalodimitrakis, {Emmanuel N.} and Anagnou, {Nicholas P.} and Pappa, {Kalliopi I.} and Golubenko, {Maria V.} and Vladimir Orekhov and Borinskaya, {Svetlana A.} and Katrin Kaldma and Schauer, {Monica A.} and Maya Simionescu and Vladislava Gusar and Elena Grechanina and Periyasamy Govindaraj and Mikhail Voevoda and Larissa Damba and Swarkar Sharma and Lalji Singh and Ornella Semino and Behar, {Doron M.} and Levon Yepiskoposyan and Richards, {Martin B.} and Mait Metspalu and Toomas Kivisild and Kumarasamy Thangaraj and Phillip Endicott and Gyaneshwer Chaubey and Antonio Torroni and Richard Villems",
year = "2017",
month = "4",
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doi = "10.1038/srep46044",
language = "English",
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journal = "Scientific Reports",
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Sahakyan, H, Kashani, BH, Tamang, R, Kushniarevich, A, Francis, A, Costa, MD, Pathak, AK, Khachatryan, Z, Sharma, I, Van Oven, M, Parik, J, Hovhannisyan, H, Metspalu, E, Pennarun, E, Karmin, M, Tamm, E, Tambets, K, Bahmanimehr, A, Reisberg, T, Reidla, M, Achilli, A, Olivieri, A, Gandini, F, Perego, UA, Al-Zahery, N, Houshmand, M, Sanati, MH, Soares, P, Rai, E, Šarac, J, Šarić, T, Sharma, V, Pereira, L, Fernandes, V, Černý, V, Farjadian, S, Singh, DP, Azakli, H, Üstek, D, Trofimova, NE, Kutuev, I, Litvinov, S, Bermisheva, M, Khusnutdinova, EK, Rai, N, Singh, M, Singh, VK, Reddy, AG, Tolk, HV, Cvjetan, S, Lauc, LB, Rudan, P, Michalodimitrakis, EN, Anagnou, NP, Pappa, KI, Golubenko, MV, Orekhov, V, Borinskaya, SA, Kaldma, K, Schauer, MA, Simionescu, M, Gusar, V, Grechanina, E, Govindaraj, P, Voevoda, M, Damba, L, Sharma, S, Singh, L, Semino, O, Behar, DM, Yepiskoposyan, L, Richards, MB, Metspalu, M, Kivisild, T, Thangaraj, K, Endicott, P, Chaubey, G, Torroni, A & Villems, R 2017, 'Origin and spread of human mitochondrial DNA haplogroup U7', Scientific Reports, vol. 7, 46044. https://doi.org/10.1038/srep46044

Origin and spread of human mitochondrial DNA haplogroup U7. / Sahakyan, Hovhannes; Kashani, Baharak Hooshiar; Tamang, Rakesh; Kushniarevich, Alena; Francis, Amirtharaj; Costa, Marta D.; Pathak, Ajai Kumar; Khachatryan, Zaruhi; Sharma, Indu; Van Oven, Mannis; Parik, Jüri; Hovhannisyan, Hrant; Metspalu, Ene; Pennarun, Erwan; Karmin, Monika; Tamm, Erika; Tambets, Kristiina; Bahmanimehr, Ardeshir; Reisberg, Tuuli; Reidla, Maere; Achilli, Alessandro; Olivieri, Anna; Gandini, Francesca; Perego, Ugo A.; Al-Zahery, Nadia; Houshmand, Massoud; Sanati, Mohammad Hossein; Soares, Pedro; Rai, Ekta; Šarac, Jelena; Šarić, Tena; Sharma, Varun; Pereira, Luisa; Fernandes, Veronica; Černý, Viktor; Farjadian, Shirin; Singh, Deepankar Pratap; Azakli, Hülya; Üstek, Duran; Trofimova, Natalia Ekomasova; Kutuev, Ildus; Litvinov, Sergei; Bermisheva, Marina; Khusnutdinova, Elza K.; Rai, Niraj; Singh, Manvendra; Singh, Vijay Kumar; Reddy, Alla G.; Tolk, Helle Viivi; Cvjetan, Svjetlana; Lauc, Lovorka Barac; Rudan, Pavao; Michalodimitrakis, Emmanuel N.; Anagnou, Nicholas P.; Pappa, Kalliopi I.; Golubenko, Maria V.; Orekhov, Vladimir; Borinskaya, Svetlana A.; Kaldma, Katrin; Schauer, Monica A.; Simionescu, Maya; Gusar, Vladislava; Grechanina, Elena; Govindaraj, Periyasamy; Voevoda, Mikhail; Damba, Larissa; Sharma, Swarkar; Singh, Lalji; Semino, Ornella; Behar, Doron M.; Yepiskoposyan, Levon; Richards, Martin B.; Metspalu, Mait; Kivisild, Toomas; Thangaraj, Kumarasamy; Endicott, Phillip; Chaubey, Gyaneshwer; Torroni, Antonio; Villems, Richard.

In: Scientific Reports, Vol. 7, 46044, 07.04.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Origin and spread of human mitochondrial DNA haplogroup U7

AU - Sahakyan, Hovhannes

AU - Kashani, Baharak Hooshiar

AU - Tamang, Rakesh

AU - Kushniarevich, Alena

AU - Francis, Amirtharaj

AU - Costa, Marta D.

AU - Pathak, Ajai Kumar

AU - Khachatryan, Zaruhi

AU - Sharma, Indu

AU - Van Oven, Mannis

AU - Parik, Jüri

AU - Hovhannisyan, Hrant

AU - Metspalu, Ene

AU - Pennarun, Erwan

AU - Karmin, Monika

AU - Tamm, Erika

AU - Tambets, Kristiina

AU - Bahmanimehr, Ardeshir

AU - Reisberg, Tuuli

AU - Reidla, Maere

AU - Achilli, Alessandro

AU - Olivieri, Anna

AU - Gandini, Francesca

AU - Perego, Ugo A.

AU - Al-Zahery, Nadia

AU - Houshmand, Massoud

AU - Sanati, Mohammad Hossein

AU - Soares, Pedro

AU - Rai, Ekta

AU - Šarac, Jelena

AU - Šarić, Tena

AU - Sharma, Varun

AU - Pereira, Luisa

AU - Fernandes, Veronica

AU - Černý, Viktor

AU - Farjadian, Shirin

AU - Singh, Deepankar Pratap

AU - Azakli, Hülya

AU - Üstek, Duran

AU - Trofimova, Natalia Ekomasova

AU - Kutuev, Ildus

AU - Litvinov, Sergei

AU - Bermisheva, Marina

AU - Khusnutdinova, Elza K.

AU - Rai, Niraj

AU - Singh, Manvendra

AU - Singh, Vijay Kumar

AU - Reddy, Alla G.

AU - Tolk, Helle Viivi

AU - Cvjetan, Svjetlana

AU - Lauc, Lovorka Barac

AU - Rudan, Pavao

AU - Michalodimitrakis, Emmanuel N.

AU - Anagnou, Nicholas P.

AU - Pappa, Kalliopi I.

AU - Golubenko, Maria V.

AU - Orekhov, Vladimir

AU - Borinskaya, Svetlana A.

AU - Kaldma, Katrin

AU - Schauer, Monica A.

AU - Simionescu, Maya

AU - Gusar, Vladislava

AU - Grechanina, Elena

AU - Govindaraj, Periyasamy

AU - Voevoda, Mikhail

AU - Damba, Larissa

AU - Sharma, Swarkar

AU - Singh, Lalji

AU - Semino, Ornella

AU - Behar, Doron M.

AU - Yepiskoposyan, Levon

AU - Richards, Martin B.

AU - Metspalu, Mait

AU - Kivisild, Toomas

AU - Thangaraj, Kumarasamy

AU - Endicott, Phillip

AU - Chaubey, Gyaneshwer

AU - Torroni, Antonio

AU - Villems, Richard

PY - 2017/4/7

Y1 - 2017/4/7

N2 - Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

AB - Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

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U2 - 10.1038/srep46044

DO - 10.1038/srep46044

M3 - Article

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 46044

ER -

Sahakyan H, Kashani BH, Tamang R, Kushniarevich A, Francis A, Costa MD et al. Origin and spread of human mitochondrial DNA haplogroup U7. Scientific Reports. 2017 Apr 7;7. 46044. https://doi.org/10.1038/srep46044