Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen Xiu Ni; Wai Lun Man; Myra Ting Wai Cheung; Raymond Wai Yin Sun; Yuan Lan Shu; Yun Wah Lam; Chi Ming Che; Tai Chu Lau

doi:10.1039/c0cc04515b

Osmium(vi) complexes as a new class of potential anti-cancer agents

Wen Xiu Ni, Wai Lun Man, Myra Ting Wai Cheung, Raymond Wai Yin Sun, Yuan Lan Shu, Yun Wah Lam, Chi Ming Che, Tai Chu Lau

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

A nitridoosmium(vi) complex [Os^VI(N)(sap)(OH₂)Cl] (H₂sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

Original language	English
Pages (from-to)	2140-2142
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	7
Early online date	4 Jan 2011
DOIs	https://doi.org/10.1039/c0cc04515b
Publication status	Published - 21 Feb 2011
Externally published	Yes

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title = "Osmium(vi) complexes as a new class of potential anti-cancer agents",

abstract = "A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.",

keywords = "cancer cell, human cell, cell cycle G2 phase",

author = "Ni, {Wen Xiu} and Man, {Wai Lun} and Cheung, {Myra Ting Wai} and Sun, {Raymond Wai Yin} and Shu, {Yuan Lan} and Lam, {Yun Wah} and Che, {Chi Ming} and Lau, {Tai Chu}",

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T1 - Osmium(vi) complexes as a new class of potential anti-cancer agents

AU - Ni, Wen Xiu

AU - Man, Wai Lun

AU - Cheung, Myra Ting Wai

AU - Sun, Raymond Wai Yin

AU - Shu, Yuan Lan

AU - Lam, Yun Wah

AU - Che, Chi Ming

AU - Lau, Tai Chu

PY - 2011/2/21

Y1 - 2011/2/21

N2 - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

AB - A nitridoosmium(vi) complex [OsVI(N)(sap)(OH2)Cl] (H2sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S- and G2/M-phase arrest and forms a stable adduct with dianionic 5′-guanosine monophosphate.

KW - cancer cell

KW - human cell

KW - cell cycle G2 phase

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U2 - 10.1039/c0cc04515b

DO - 10.1039/c0cc04515b

M3 - Article

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SP - 2140

EP - 2142

JO - Chemical Communications

JF - Chemical Communications

IS - 7

ER -

Osmium(vi) complexes as a new class of potential anti-cancer agents

Abstract

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