Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni, Wai Lun Man, Shek Man Yiu, Man Ho, Myra Ting Wai Cheung, Chi Chiu Ko, Chi Ming Che, Yun Wah Lam, Tai Chu Lau

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47 Citations (Scopus)


Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

Original languageEnglish
Pages (from-to)1582-1588
Number of pages7
JournalChemical Science
Issue number5
Early online date3 Feb 2012
Publication statusPublished - 1 May 2012
Externally publishedYes

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