Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni; Wai Lun Man; Shek Man Yiu; Man Ho; Myra Ting Wai Cheung; Chi Chiu Ko; Chi Ming Che; Yun Wah Lam; Tai Chu Lau

doi:10.1039/c2sc01031c

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Wen Xiu Ni, Wai Lun Man, Shek Man Yiu, Man Ho, Myra Ting Wai Cheung, Chi Chiu Ko, Chi Ming Che, Yun Wah Lam, Tai Chu Lau

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Eight new nitridoosmium(vi) complexes with the general formula [Os ^VI(N)Cl ₃(Hazole) ₂] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

Original language	English
Pages (from-to)	1582-1588
Number of pages	7
Journal	Chemical Science
Volume	3
Issue number	5
Early online date	3 Feb 2012
DOIs	https://doi.org/10.1039/c2sc01031c
Publication status	Published - 1 May 2012
Externally published	Yes

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title = "Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents",

abstract = "Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.",

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author = "Ni, {Wen Xiu} and Man, {Wai Lun} and Yiu, {Shek Man} and Man Ho and Cheung, {Myra Ting Wai} and Ko, {Chi Chiu} and Che, {Chi Ming} and Lam, {Yun Wah} and Lau, {Tai Chu}",

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T1 - Osmium(vi) nitrido complexes bearing azole heterocycles

T2 - A new class of antitumor agents

AU - Ni, Wen Xiu

AU - Man, Wai Lun

AU - Yiu, Shek Man

AU - Ho, Man

AU - Cheung, Myra Ting Wai

AU - Ko, Chi Chiu

AU - Che, Chi Ming

AU - Lam, Yun Wah

AU - Lau, Tai Chu

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

AB - Eight new nitridoosmium(vi) complexes with the general formula [Os VI(N)Cl 3(Hazole) 2] have been synthesized and characterized. The cellular uptake and the antiproliferative activities of these compounds against a panel of human cancer cell lines have been investigated. Complexes with pyrazole derivatives (1, 2, 3 and 4) are found to possess significant in vitro cytotoxicity. Further studies of compounds 1 and 3 indicate that they induce S phase arrest in HeLa cells followed by apoptosis, possibly as a result of binding with DNA.

KW - Cell culture

KW - Cell death

KW - Osmium

KW - Synthesis (chemical)

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DO - 10.1039/c2sc01031c

M3 - Article

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SP - 1582

EP - 1588

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 5

ER -

Osmium(vi) nitrido complexes bearing azole heterocycles: A new class of antitumor agents

Abstract

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