Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

Laura Jadkauskaite, Pierre A. Coulombe, Matthias Schäfer, Albena T. Dinkova-Kostova, Ralf Paus, Iain Haslam

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.
LanguageEnglish
Article number1700029
Number of pages9
JournalBioEssays
Volume39
Issue number8
Early online date7 Jul 2017
DOIs
Publication statusPublished - Aug 2017

Fingerprint

Oxidative stress
Hair Follicle
Oxidative Stress
Aging of materials
Chemical activation
Oxidation-Reduction
Chemotherapy
Poisons
Alopecia
Peroxides
Pathology
Reactive Oxygen Species
NF-E2 Transcription Factor
Transcription Factors
Irradiation
Neurogenic Inflammation
Hair Removal
Alopecia Areata
Defects
Molecules

Cite this

Jadkauskaite, Laura ; Coulombe, Pierre A. ; Schäfer, Matthias ; Dinkova-Kostova, Albena T. ; Paus, Ralf ; Haslam, Iain. / Oxidative Stress Management in the Hair Follicle : Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?. In: BioEssays. 2017 ; Vol. 39, No. 8.
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abstract = "Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.",
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Oxidative Stress Management in the Hair Follicle : Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond? / Jadkauskaite, Laura; Coulombe, Pierre A.; Schäfer, Matthias; Dinkova-Kostova, Albena T.; Paus, Ralf; Haslam, Iain.

In: BioEssays, Vol. 39, No. 8, 1700029, 08.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Oxidative Stress Management in the Hair Follicle

T2 - BioEssays

AU - Jadkauskaite, Laura

AU - Coulombe, Pierre A.

AU - Schäfer, Matthias

AU - Dinkova-Kostova, Albena T.

AU - Paus, Ralf

AU - Haslam, Iain

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AB - Widespread expression of the transcription factor, nuclear factor (erythroid-derived 2)-like 2 (NRF2), which maintains redox homeostasis, has recently been identified in the hair follicle (HF). Small molecule activators of NRF2 may therefore be useful in the management of HF pathologies associated with redox imbalance, ranging from HF greying and HF ageing via androgenetic alopecia and alopecia areata to chemotherapy-induced hair loss. Indeed, NRF2 activation has been shown to prevent peroxide-induced hair growth inhibition. Multiple parameters can increase the levels of reactive oxygen species in the HF, for example melanogenesis, depilation-induced trauma, neurogenic and autoimmune inflammation, toxic drugs, environmental stressors such as UV irradiation, genetic defects and aging-associated mitochondrial dysfunction. In this review, the potential mechanisms whereby NRF2 activation could prove beneficial in treatment of redox-associated HF disorders are therefore discussed.

KW - Alopecia

KW - Chemotherapy and hair follicle

KW - Hair greying

KW - Inflammation

KW - NRF2

KW - Oxidative stress

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