Paleolithic and Neolithic Lineages in the European Mitochondrial Gene Pool

M. Richards, H. Corte-Real, P. Forster, V. Macaulay, H. Wilkinson-Herbots, A. Demaine, S. Papiha, R. Hedges, H. J. Bandelt, B. Sykes

Research output: Contribution to journalArticle

380 Citations (Scopus)

Abstract

Phylogenetic and diversity analysis of the mtDNA control region sequence variation of 821 individuals from Europe and the Middle East distinguishes five major lineage groups with different internal diversities and divergence times. Consideration of the diversities and geographic distribution of these groups within Europe and the Middle East leads to the conclusion that ancestors of the great majority of modern, extant lineages entered Europe during the Upper Paleolithic. A further set of lineages arrived from the Middle East much later, and their age and geographic distribution within Europe correlates well with archaeological evidence for two culturally and geographically distinct Neolithic colonization events that are associated with the spread of agriculture. It follows from this interpretation that the major extant lineages throughout Europe predate the Neolithic expansion and that the spread of agriculture was a substantially indigenous development accompanied by only a relatively minor component of contemporary Middle Eastern agriculturalists. There is no evidence of any surviving Neanderthal lineages among modern Europeans.

LanguageEnglish
Pages185-203
Number of pages19
JournalAmerican Journal of Human Genetics
Volume59
Issue number1
Publication statusPublished - Jul 1996
Externally publishedYes

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Gene Pool
Mitochondrial Genes
Middle East
Agriculture
Neanderthals
Age Distribution
Prednisolone
Mitochondrial DNA

Cite this

Richards, M., Corte-Real, H., Forster, P., Macaulay, V., Wilkinson-Herbots, H., Demaine, A., ... Sykes, B. (1996). Paleolithic and Neolithic Lineages in the European Mitochondrial Gene Pool. American Journal of Human Genetics, 59(1), 185-203.
Richards, M. ; Corte-Real, H. ; Forster, P. ; Macaulay, V. ; Wilkinson-Herbots, H. ; Demaine, A. ; Papiha, S. ; Hedges, R. ; Bandelt, H. J. ; Sykes, B. / Paleolithic and Neolithic Lineages in the European Mitochondrial Gene Pool. In: American Journal of Human Genetics. 1996 ; Vol. 59, No. 1. pp. 185-203.
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Richards, M, Corte-Real, H, Forster, P, Macaulay, V, Wilkinson-Herbots, H, Demaine, A, Papiha, S, Hedges, R, Bandelt, HJ & Sykes, B 1996, 'Paleolithic and Neolithic Lineages in the European Mitochondrial Gene Pool', American Journal of Human Genetics, vol. 59, no. 1, pp. 185-203.

Paleolithic and Neolithic Lineages in the European Mitochondrial Gene Pool. / Richards, M.; Corte-Real, H.; Forster, P.; Macaulay, V.; Wilkinson-Herbots, H.; Demaine, A.; Papiha, S.; Hedges, R.; Bandelt, H. J.; Sykes, B.

In: American Journal of Human Genetics, Vol. 59, No. 1, 07.1996, p. 185-203.

Research output: Contribution to journalArticle

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Richards M, Corte-Real H, Forster P, Macaulay V, Wilkinson-Herbots H, Demaine A et al. Paleolithic and Neolithic Lineages in the European Mitochondrial Gene Pool. American Journal of Human Genetics. 1996 Jul;59(1):185-203.