Patent for Wearable cryo-compression device to address an unmet clinical need – Chemotherapy-Induced Peripheral Neuropathy

The invention relates to a compression wrap and method for temperature-controlled application of pressure on an arm of a subject, comprising a fluid bladder comprising a first element comprising two or more first flaps, a second element comprising one or more digital flaps, and a third element comprising two or more second flaps, wherein the first element and the third element are connected along a first edge and the second element is connected to the first element and the third element along a second edge. In one specific embodiment, the fluid bladder comprises an air cavity and a liquid cavity.