Patient-Reported Adverse Drug Reactions and Drug-Drug Interactions: A Cross-Sectional Study on Malaysian HIV/AIDS Patients

Syed S. Hasan, See C. Keong, Christopher L K Choong, Syed I. Ahmed, Ting W. Ching, Mudassir Anwar, Keivan Ahmadi, Muneer G. Babar

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: This study aimed to explore the adverse drug reactions (ADRs) reported by patients and to identify drug-drug interactions (DDIs) among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Subjects and Methods: This cross-sectional study was conducted at the Medication Therapy Adherence Clinic, Hospital Sungai Buloh, an HIV/AIDS referral centre. The patients were randomly selected and were encouraged to describe ADRs caused specifically by any of the prescribed antiretroviral drugs (ARDs). Sociodemographic characteristics were recorded from the patients' medical records. In addition data on antiretroviral treatment (ART), DDIs and other conventional medication were also documented. Results: A total of 325 randomly selected HIV/AIDS patients with a mean age of 22.94 years participated in the study. The most frequently prescribed ARDs were lamivudine (64.6%), zidovudine (40.6%) and efavirenz (42.5%). Commonly reported ADRs were fatigue (54.8%), allergic reactions (41.5%), weight loss (41.5%), dry mouth (35.1%) and memory loss (35.1%). Female (87.8%), non-complementary and alternative medicine (CAM) users (87.3%) and participants below 50 years old (81.1%) were identified as having a higher prevalence of ADRs compared to males (79.6%), CAM users (78.7%) and participants aged 50 years or more (77.5%). Patient age was found to be significantly associated (p = 0.048) with the ADRs. In addition, a total of 44 cases of DDIs belonging to category D were also found in this study. Conclusions: This study enabled us to identify the most common ADRs and DDIs associated with the use of ART. Safe and effective treatment depends on the healthcare providers' knowledge of the same.

LanguageEnglish
Pages265-270
Number of pages6
JournalMedical Principles and Practice
Volume20
Issue number3
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Fingerprint

Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
HIV
Complementary Therapies
Pharmaceutical Preparations
efavirenz
Lamivudine
Medication Adherence
Zidovudine
Memory Disorders
Therapeutics
Health Personnel
Medical Records
Fatigue
Mouth
Weight Loss
Hypersensitivity
Referral and Consultation

Cite this

Hasan, Syed S. ; Keong, See C. ; Choong, Christopher L K ; Ahmed, Syed I. ; Ching, Ting W. ; Anwar, Mudassir ; Ahmadi, Keivan ; Babar, Muneer G. / Patient-Reported Adverse Drug Reactions and Drug-Drug Interactions : A Cross-Sectional Study on Malaysian HIV/AIDS Patients. In: Medical Principles and Practice. 2011 ; Vol. 20, No. 3. pp. 265-270.
@article{00aee9b4a7c948658c1030d1bd16e71c,
title = "Patient-Reported Adverse Drug Reactions and Drug-Drug Interactions: A Cross-Sectional Study on Malaysian HIV/AIDS Patients",
abstract = "Objective: This study aimed to explore the adverse drug reactions (ADRs) reported by patients and to identify drug-drug interactions (DDIs) among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Subjects and Methods: This cross-sectional study was conducted at the Medication Therapy Adherence Clinic, Hospital Sungai Buloh, an HIV/AIDS referral centre. The patients were randomly selected and were encouraged to describe ADRs caused specifically by any of the prescribed antiretroviral drugs (ARDs). Sociodemographic characteristics were recorded from the patients' medical records. In addition data on antiretroviral treatment (ART), DDIs and other conventional medication were also documented. Results: A total of 325 randomly selected HIV/AIDS patients with a mean age of 22.94 years participated in the study. The most frequently prescribed ARDs were lamivudine (64.6{\%}), zidovudine (40.6{\%}) and efavirenz (42.5{\%}). Commonly reported ADRs were fatigue (54.8{\%}), allergic reactions (41.5{\%}), weight loss (41.5{\%}), dry mouth (35.1{\%}) and memory loss (35.1{\%}). Female (87.8{\%}), non-complementary and alternative medicine (CAM) users (87.3{\%}) and participants below 50 years old (81.1{\%}) were identified as having a higher prevalence of ADRs compared to males (79.6{\%}), CAM users (78.7{\%}) and participants aged 50 years or more (77.5{\%}). Patient age was found to be significantly associated (p = 0.048) with the ADRs. In addition, a total of 44 cases of DDIs belonging to category D were also found in this study. Conclusions: This study enabled us to identify the most common ADRs and DDIs associated with the use of ART. Safe and effective treatment depends on the healthcare providers' knowledge of the same.",
keywords = "Drug-drug interactions, HIV/AIDS, Malaysians, Patient-reported adverse drug reactions",
author = "Hasan, {Syed S.} and Keong, {See C.} and Choong, {Christopher L K} and Ahmed, {Syed I.} and Ching, {Ting W.} and Mudassir Anwar and Keivan Ahmadi and Babar, {Muneer G.}",
year = "2011",
month = "3",
doi = "10.1159/000321274",
language = "English",
volume = "20",
pages = "265--270",
journal = "Medical Principles and Practice",
issn = "1011-7571",
publisher = "S. Karger AG",
number = "3",

}

Patient-Reported Adverse Drug Reactions and Drug-Drug Interactions : A Cross-Sectional Study on Malaysian HIV/AIDS Patients. / Hasan, Syed S.; Keong, See C.; Choong, Christopher L K; Ahmed, Syed I.; Ching, Ting W.; Anwar, Mudassir; Ahmadi, Keivan; Babar, Muneer G.

In: Medical Principles and Practice, Vol. 20, No. 3, 03.2011, p. 265-270.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Patient-Reported Adverse Drug Reactions and Drug-Drug Interactions

T2 - Medical Principles and Practice

AU - Hasan, Syed S.

AU - Keong, See C.

AU - Choong, Christopher L K

AU - Ahmed, Syed I.

AU - Ching, Ting W.

AU - Anwar, Mudassir

AU - Ahmadi, Keivan

AU - Babar, Muneer G.

PY - 2011/3

Y1 - 2011/3

N2 - Objective: This study aimed to explore the adverse drug reactions (ADRs) reported by patients and to identify drug-drug interactions (DDIs) among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Subjects and Methods: This cross-sectional study was conducted at the Medication Therapy Adherence Clinic, Hospital Sungai Buloh, an HIV/AIDS referral centre. The patients were randomly selected and were encouraged to describe ADRs caused specifically by any of the prescribed antiretroviral drugs (ARDs). Sociodemographic characteristics were recorded from the patients' medical records. In addition data on antiretroviral treatment (ART), DDIs and other conventional medication were also documented. Results: A total of 325 randomly selected HIV/AIDS patients with a mean age of 22.94 years participated in the study. The most frequently prescribed ARDs were lamivudine (64.6%), zidovudine (40.6%) and efavirenz (42.5%). Commonly reported ADRs were fatigue (54.8%), allergic reactions (41.5%), weight loss (41.5%), dry mouth (35.1%) and memory loss (35.1%). Female (87.8%), non-complementary and alternative medicine (CAM) users (87.3%) and participants below 50 years old (81.1%) were identified as having a higher prevalence of ADRs compared to males (79.6%), CAM users (78.7%) and participants aged 50 years or more (77.5%). Patient age was found to be significantly associated (p = 0.048) with the ADRs. In addition, a total of 44 cases of DDIs belonging to category D were also found in this study. Conclusions: This study enabled us to identify the most common ADRs and DDIs associated with the use of ART. Safe and effective treatment depends on the healthcare providers' knowledge of the same.

AB - Objective: This study aimed to explore the adverse drug reactions (ADRs) reported by patients and to identify drug-drug interactions (DDIs) among human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Subjects and Methods: This cross-sectional study was conducted at the Medication Therapy Adherence Clinic, Hospital Sungai Buloh, an HIV/AIDS referral centre. The patients were randomly selected and were encouraged to describe ADRs caused specifically by any of the prescribed antiretroviral drugs (ARDs). Sociodemographic characteristics were recorded from the patients' medical records. In addition data on antiretroviral treatment (ART), DDIs and other conventional medication were also documented. Results: A total of 325 randomly selected HIV/AIDS patients with a mean age of 22.94 years participated in the study. The most frequently prescribed ARDs were lamivudine (64.6%), zidovudine (40.6%) and efavirenz (42.5%). Commonly reported ADRs were fatigue (54.8%), allergic reactions (41.5%), weight loss (41.5%), dry mouth (35.1%) and memory loss (35.1%). Female (87.8%), non-complementary and alternative medicine (CAM) users (87.3%) and participants below 50 years old (81.1%) were identified as having a higher prevalence of ADRs compared to males (79.6%), CAM users (78.7%) and participants aged 50 years or more (77.5%). Patient age was found to be significantly associated (p = 0.048) with the ADRs. In addition, a total of 44 cases of DDIs belonging to category D were also found in this study. Conclusions: This study enabled us to identify the most common ADRs and DDIs associated with the use of ART. Safe and effective treatment depends on the healthcare providers' knowledge of the same.

KW - Drug-drug interactions

KW - HIV/AIDS

KW - Malaysians

KW - Patient-reported adverse drug reactions

UR - http://www.scopus.com/inward/record.url?scp=79953670080&partnerID=8YFLogxK

UR - https://www.karger.com/Journal/Home/224259

U2 - 10.1159/000321274

DO - 10.1159/000321274

M3 - Article

VL - 20

SP - 265

EP - 270

JO - Medical Principles and Practice

JF - Medical Principles and Practice

SN - 1011-7571

IS - 3

ER -