Pax genes in embryogenesis and oncogenesis

Qiuyu Wang, Wen Hui Fang, Jerzy Krupinski, Shant Kumar, Mark Slevin, Patricia Kumar

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The paired box genes are a family of nine developmental control genes, which in human beings (PAX) and mice (Pax) encode nuclear transcription factors. The temporal and spatial expressions of these highly conserved genes are tightly regulated during foetal development including organogenesis. PAY/Paxgenes are switched off during the terminal differentiation of most structures. Specific mutations within a number of PAX/Pax genes lead to developmental abnormalities in both human beings and mice. Mutation in PAX3 causes Waardenburg syndrome, and craniofacial-deafness-hand syndrome. The Splotch phenotype in mouse exhibits defects in neural crest derivatives such as, pigment cells, sympathetic ganglia and cardiac neural crest-derived structures. The PAX family also plays key roles in several human malignancies. In particular, PAX3 is involved in rhabdomyosarcoma and tumours of neural crest origin, including melanoma and neuroblastoma. This review critically evaluates the roles of PAX/Pax in oncogenesis. It especially highlights recent advances in knowledge of how their genetic alterations directly interfere in the transcriptional networks that regulate cell differentiation, proliferation, migration and survival and may contribute to oncogenesis.

Original languageEnglish
Pages (from-to)2281-2294
Number of pages14
JournalJournal of Cellular and Molecular Medicine
Volume12
Issue number6A
Early online date8 Jul 2008
DOIs
Publication statusPublished - 1 Dec 2008
Externally publishedYes

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    Wang, Q., Fang, W. H., Krupinski, J., Kumar, S., Slevin, M., & Kumar, P. (2008). Pax genes in embryogenesis and oncogenesis. Journal of Cellular and Molecular Medicine, 12(6A), 2281-2294. https://doi.org/10.1111/j.1582-4934.2008.00427.x