Peripheral Refractive Changes Associated with Myopia Progression

Hema Radhakrishnan, Peter M. Allen, Richard I. Calver, Baskar Babu Pitty Theagarayan, Holly Price, Sheila Rae, Ananth Sailoganathan, Daniel J. O'leary

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Abstract

Purpose.: To evaluate the changes in peripheral refraction profiles associated with myopia progression and treatment modalities used in the Cambridge Anti-Myopia Study.Methods.: One hundred and seventy-seven myopes in the age range of 14 to 22 years were enrolled in the study. The mean spherical equivalent refractive error was −3.12 ± 1.87 diopters (D) and the refractive error of each participant was corrected with contact lenses. The participants were randomly assigned to one of four treatment groups, which included: altered spherical aberration and vision training, altered spherical aberration only, vision training only, and control. Peripheral refractive error was measured using an open field autorefractor in the central 60° of the retina in 10° steps. The refractive error was measured using cycloplegic autorefraction. Two-year refractive progression data and initial peripheral refraction measurements were available in 113 participants. Measurements of peripheral refraction and cycloplegic refraction were obtained at three visits over 2 years in 12-month intervals for 92 participants.Results.: All subjects showed a relative peripheral hyperopia, especially in the nasal retina. A limited magnitude of myopia progression of −0.34 ± 0.36 D over 2 years was found in each of the four groups on average. There were no significant differences in the rate of progression between any of the treatment groups (P > 0.05). Initial peripheral J45 astigmatic refractive error at 20° and 30° in the nasal retina was weakly correlated with progression of myopia over 2 years (r = −0.27, P = 0.004 and r = −0.20, P = 0.040, respectively; n = 113). The change in spherical equivalent peripheral refractive error at 30° nasal retina over time was also significantly correlated with progression of myopia especially at 24 months (r = −0.24, P = 0.017, n = 92).Conclusions.: Relative peripheral hyperopia is associated with myopia. Myopia progression may be weakly linked to changes in the peripheral refraction profiles in the nasal retina. However, a causative link between peripheral refractive error and myopia progression could not be established.
Original languageEnglish
Pages (from-to)1573-1581
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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    Radhakrishnan, H., Allen, P. M., Calver, R. I., Pitty Theagarayan, B. B., Price, H., Rae, S., Sailoganathan, A., & O'leary, D. J. (2013). Peripheral Refractive Changes Associated with Myopia Progression. Investigative Ophthalmology and Visual Science, 54(2), 1573-1581. https://doi.org/10.1167/iovs.12-10278