Personalized 3D printed ciprofloxacin impregnated meshes for the management of hernia

Nadia Qamar; Nasir  Abbas; Muhammad Irfan; Amjad Hussain; Muhammad Sohail Arshad; Sumera Latif; Faisal Mehmood; Muhammad Usman  Ghori

doi:10.1016/j.jddst.2019.101164

Personalized 3D printed ciprofloxacin impregnated meshes for the management of hernia

Nadia Qamar, Nasir Abbas, Muhammad Irfan, Amjad Hussain, Muhammad Sohail Arshad, Sumera Latif, Faisal Mehmood, Muhammad Usman Ghori

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

This study aims to explore the application of fused deposition modeling (FDM) 3D printing in the fabrication of personalized hernial meshes. Different meshes with and without the loading of ciprofloxacin HCl were designed using polypropylene (PP) and polyvinyl alcohol (PVA), having different pore size, shape and thread thickness. PP has shown better printability than PVA. Printed meshes were evaluated for their mechanical, drug loading and release characteristics. All the printed meshes showed satisfactory mechanical properties. However, the PVA meshes showed slightly faster release as compared to PP based meshes. Moreover, in-vivo testing in rabbit models (performed for assessing biocompatibility and adhesiogenecity) revealed no signs of implant rejection and the extent of adhesions to the visceral tissue was mild to moderate. Animals implanted with ciprofloxacin HCl loaded meshes exhibited fewer fluctuations in body temperature and faster-wound healing. This work demonstrated that the FDM 3D printing is an effective and low-cost alternative for the manufacturing of tailored meshes with or without drug loading for the management of hernia.

Original language	English
Article number	101164
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of Drug Delivery Science and Technology
Volume	53
Early online date	18 Jul 2019
DOIs	https://doi.org/10.1016/j.jddst.2019.101164
Publication status	Published - 1 Oct 2019

Access to Document

10.1016/j.jddst.2019.101164Licence: Unspecified

Latif_et_al._Accepted_Version_Accepted author manuscript, 1.43 MBLicence: CC BY-NC-ND

Cite this

@article{0a3e0191bea340b5a9d029891dfd9f44,

title = "Personalized 3D printed ciprofloxacin impregnated meshes for the management of hernia",

abstract = "This study aims to explore the application of fused deposition modeling (FDM) 3D printing in the fabrication of personalized hernial meshes. Different meshes with and without the loading of ciprofloxacin HCl were designed using polypropylene (PP) and polyvinyl alcohol (PVA), having different pore size, shape and thread thickness. PP has shown better printability than PVA. Printed meshes were evaluated for their mechanical, drug loading and release characteristics. All the printed meshes showed satisfactory mechanical properties. However, the PVA meshes showed slightly faster release as compared to PP based meshes. Moreover, in-vivo testing in rabbit models (performed for assessing biocompatibility and adhesiogenecity) revealed no signs of implant rejection and the extent of adhesions to the visceral tissue was mild to moderate. Animals implanted with ciprofloxacin HCl loaded meshes exhibited fewer fluctuations in body temperature and faster-wound healing. This work demonstrated that the FDM 3D printing is an effective and low-cost alternative for the manufacturing of tailored meshes with or without drug loading for the management of hernia.",

keywords = "3D printing, Fused deposition modeling, Hernia mesh, Ciprofloxacin HCl, Tensile strength, Polypropylene, Polyvinyl alcohol",

author = "Nadia Qamar and Nasir Abbas and Muhammad Irfan and Amjad Hussain and Arshad, {Muhammad Sohail} and Sumera Latif and Faisal Mehmood and Ghori, {Muhammad Usman}",

year = "2019",

month = oct,

day = "1",

doi = "10.1016/j.jddst.2019.101164",

language = "English",

volume = "53",

pages = "1--8",

journal = "Journal of Drug Delivery Science and Technology",

issn = "1773-2247",

publisher = "Editions de Sante",

}

TY - JOUR

T1 - Personalized 3D printed ciprofloxacin impregnated meshes for the management of hernia

AU - Qamar, Nadia

AU - Abbas, Nasir

AU - Irfan, Muhammad

AU - Hussain, Amjad

AU - Arshad, Muhammad Sohail

AU - Latif, Sumera

AU - Mehmood, Faisal

AU - Ghori, Muhammad Usman

PY - 2019/10/1

Y1 - 2019/10/1

N2 - This study aims to explore the application of fused deposition modeling (FDM) 3D printing in the fabrication of personalized hernial meshes. Different meshes with and without the loading of ciprofloxacin HCl were designed using polypropylene (PP) and polyvinyl alcohol (PVA), having different pore size, shape and thread thickness. PP has shown better printability than PVA. Printed meshes were evaluated for their mechanical, drug loading and release characteristics. All the printed meshes showed satisfactory mechanical properties. However, the PVA meshes showed slightly faster release as compared to PP based meshes. Moreover, in-vivo testing in rabbit models (performed for assessing biocompatibility and adhesiogenecity) revealed no signs of implant rejection and the extent of adhesions to the visceral tissue was mild to moderate. Animals implanted with ciprofloxacin HCl loaded meshes exhibited fewer fluctuations in body temperature and faster-wound healing. This work demonstrated that the FDM 3D printing is an effective and low-cost alternative for the manufacturing of tailored meshes with or without drug loading for the management of hernia.

AB - This study aims to explore the application of fused deposition modeling (FDM) 3D printing in the fabrication of personalized hernial meshes. Different meshes with and without the loading of ciprofloxacin HCl were designed using polypropylene (PP) and polyvinyl alcohol (PVA), having different pore size, shape and thread thickness. PP has shown better printability than PVA. Printed meshes were evaluated for their mechanical, drug loading and release characteristics. All the printed meshes showed satisfactory mechanical properties. However, the PVA meshes showed slightly faster release as compared to PP based meshes. Moreover, in-vivo testing in rabbit models (performed for assessing biocompatibility and adhesiogenecity) revealed no signs of implant rejection and the extent of adhesions to the visceral tissue was mild to moderate. Animals implanted with ciprofloxacin HCl loaded meshes exhibited fewer fluctuations in body temperature and faster-wound healing. This work demonstrated that the FDM 3D printing is an effective and low-cost alternative for the manufacturing of tailored meshes with or without drug loading for the management of hernia.

KW - 3D printing

KW - Fused deposition modeling

KW - Hernia mesh

KW - Ciprofloxacin HCl

KW - Tensile strength

KW - Polypropylene

KW - Polyvinyl alcohol

UR - http://www.scopus.com/inward/record.url?scp=85069545128&partnerID=8YFLogxK

U2 - 10.1016/j.jddst.2019.101164

DO - 10.1016/j.jddst.2019.101164

M3 - Article

VL - 53

SP - 1

EP - 8

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

M1 - 101164

ER -

Personalized 3D printed ciprofloxacin impregnated meshes for the management of hernia

Abstract

Access to Document

Other files and links

Fingerprint

Cite this