Pharmacological studies on Newbouldia laevis stem bark

O. A. Olajide, S. O. Awe, J. M. Makinde

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The methanotic extract of the stem bark of N. laevis was evaluated for anti-inflammatory antipyretic, analgesic, anticonvulsant activities, as well as for its effect on the phenobarbitone sleeping time, using various animal models. The extract (100-400 mg/kg) exhibited an inhibition of the carrageenan-induced oedema in the rat hind paw in a dose-related fashion. It also produced a reduction of yeast-induced pyrexia in mice and offered 100% protection against leptazol-induced seizures in mice at a dose of 400 mg/kg. Statistically significant analgesic activity was exhibited with 400 mg/kg of extract by inhibition of acetic acid-induced writhings in mice. There was a significant potentiation of the phenobarbitone sleeping time at all dose levels studied. Acute toxicity studies revealed CNS depression by a reduction in spontaneous locomotor activities in mice, but no lethality was recorded up to 4 g/kg of the extract.

LanguageEnglish
Pages439-443
Number of pages5
JournalFitoterapia
Volume68
Issue number5
Publication statusPublished - 8 Dec 1997
Externally publishedYes

Fingerprint

Pharmacology
Phenobarbital
Antipyretics
Carrageenan
Non-Steroidal Anti-Inflammatory Agents
Locomotion
Acetic Acid
Anticonvulsants
Analgesics
Edema
Seizures
Fever
Animal Models
Yeasts

Cite this

Olajide, O. A., Awe, S. O., & Makinde, J. M. (1997). Pharmacological studies on Newbouldia laevis stem bark. Fitoterapia, 68(5), 439-443.
Olajide, O. A. ; Awe, S. O. ; Makinde, J. M. / Pharmacological studies on Newbouldia laevis stem bark. In: Fitoterapia. 1997 ; Vol. 68, No. 5. pp. 439-443.
@article{124c9fd8709f401f95d020c09e661920,
title = "Pharmacological studies on Newbouldia laevis stem bark",
abstract = "The methanotic extract of the stem bark of N. laevis was evaluated for anti-inflammatory antipyretic, analgesic, anticonvulsant activities, as well as for its effect on the phenobarbitone sleeping time, using various animal models. The extract (100-400 mg/kg) exhibited an inhibition of the carrageenan-induced oedema in the rat hind paw in a dose-related fashion. It also produced a reduction of yeast-induced pyrexia in mice and offered 100{\%} protection against leptazol-induced seizures in mice at a dose of 400 mg/kg. Statistically significant analgesic activity was exhibited with 400 mg/kg of extract by inhibition of acetic acid-induced writhings in mice. There was a significant potentiation of the phenobarbitone sleeping time at all dose levels studied. Acute toxicity studies revealed CNS depression by a reduction in spontaneous locomotor activities in mice, but no lethality was recorded up to 4 g/kg of the extract.",
keywords = "Analgesic activity, Anticonvulsant activity, Antipyretic activity, Newbouldia laevis, anti-inflammatory activity, Phenobarbitone sleeping time",
author = "Olajide, {O. A.} and Awe, {S. O.} and Makinde, {J. M.}",
year = "1997",
month = "12",
day = "8",
language = "English",
volume = "68",
pages = "439--443",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier",
number = "5",

}

Olajide, OA, Awe, SO & Makinde, JM 1997, 'Pharmacological studies on Newbouldia laevis stem bark', Fitoterapia, vol. 68, no. 5, pp. 439-443.

Pharmacological studies on Newbouldia laevis stem bark. / Olajide, O. A.; Awe, S. O.; Makinde, J. M.

In: Fitoterapia, Vol. 68, No. 5, 08.12.1997, p. 439-443.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pharmacological studies on Newbouldia laevis stem bark

AU - Olajide, O. A.

AU - Awe, S. O.

AU - Makinde, J. M.

PY - 1997/12/8

Y1 - 1997/12/8

N2 - The methanotic extract of the stem bark of N. laevis was evaluated for anti-inflammatory antipyretic, analgesic, anticonvulsant activities, as well as for its effect on the phenobarbitone sleeping time, using various animal models. The extract (100-400 mg/kg) exhibited an inhibition of the carrageenan-induced oedema in the rat hind paw in a dose-related fashion. It also produced a reduction of yeast-induced pyrexia in mice and offered 100% protection against leptazol-induced seizures in mice at a dose of 400 mg/kg. Statistically significant analgesic activity was exhibited with 400 mg/kg of extract by inhibition of acetic acid-induced writhings in mice. There was a significant potentiation of the phenobarbitone sleeping time at all dose levels studied. Acute toxicity studies revealed CNS depression by a reduction in spontaneous locomotor activities in mice, but no lethality was recorded up to 4 g/kg of the extract.

AB - The methanotic extract of the stem bark of N. laevis was evaluated for anti-inflammatory antipyretic, analgesic, anticonvulsant activities, as well as for its effect on the phenobarbitone sleeping time, using various animal models. The extract (100-400 mg/kg) exhibited an inhibition of the carrageenan-induced oedema in the rat hind paw in a dose-related fashion. It also produced a reduction of yeast-induced pyrexia in mice and offered 100% protection against leptazol-induced seizures in mice at a dose of 400 mg/kg. Statistically significant analgesic activity was exhibited with 400 mg/kg of extract by inhibition of acetic acid-induced writhings in mice. There was a significant potentiation of the phenobarbitone sleeping time at all dose levels studied. Acute toxicity studies revealed CNS depression by a reduction in spontaneous locomotor activities in mice, but no lethality was recorded up to 4 g/kg of the extract.

KW - Analgesic activity

KW - Anticonvulsant activity

KW - Antipyretic activity

KW - Newbouldia laevis, anti-inflammatory activity

KW - Phenobarbitone sleeping time

UR - http://www.scopus.com/inward/record.url?scp=0030733935&partnerID=8YFLogxK

UR - https://www.sciencedirect.com/journal/fitoterapia

M3 - Article

VL - 68

SP - 439

EP - 443

JO - Fitoterapia

T2 - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 5

ER -

Olajide OA, Awe SO, Makinde JM. Pharmacological studies on Newbouldia laevis stem bark. Fitoterapia. 1997 Dec 8;68(5):439-443.