Pharmacological studies on the leaf of Psidium guajava

O. A. Olajide; S. O. Awe; J. M. Makinde

doi:10.1016/S0367-326X(98)00010-0

Pharmacological studies on the leaf of Psidium guajava

O. A. Olajide, S. O. Awe, J. M. Makinde

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

The methanol extract of the leaves of Psidium guajava was found to inhibit paw oedema induced by carrageenan in rats and pain induced by acetic acid in mice, and exhibited an antipyretic effect. Oral administration of the extract reduced intestinal transit time and prevented castor oil-induced diarrhoea in mice. A CNS depressant activity was exhibited by the extract by potentiating the phenobarbitone sleeping time in mice.

Original language	English
Pages (from-to)	25-31
Number of pages	7
Journal	Fitoterapia
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/S0367-326X(98)00010-0
Publication status	Published - 1 Feb 1999
Externally published	Yes

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10.1016/S0367-326X(98)00010-0

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title = "Pharmacological studies on the leaf of Psidium guajava",

abstract = "The methanol extract of the leaves of Psidium guajava was found to inhibit paw oedema induced by carrageenan in rats and pain induced by acetic acid in mice, and exhibited an antipyretic effect. Oral administration of the extract reduced intestinal transit time and prevented castor oil-induced diarrhoea in mice. A CNS depressant activity was exhibited by the extract by potentiating the phenobarbitone sleeping time in mice.",

keywords = "Analgesic activity, Anti-inflammatory activity, Antipyretic activity, CNS depressant activity, Psidium guajava, Spasmolytic activity",

author = "Olajide, {O. A.} and Awe, {S. O.} and Makinde, {J. M.}",

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AU - Olajide, O. A.

AU - Awe, S. O.

AU - Makinde, J. M.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - The methanol extract of the leaves of Psidium guajava was found to inhibit paw oedema induced by carrageenan in rats and pain induced by acetic acid in mice, and exhibited an antipyretic effect. Oral administration of the extract reduced intestinal transit time and prevented castor oil-induced diarrhoea in mice. A CNS depressant activity was exhibited by the extract by potentiating the phenobarbitone sleeping time in mice.

AB - The methanol extract of the leaves of Psidium guajava was found to inhibit paw oedema induced by carrageenan in rats and pain induced by acetic acid in mice, and exhibited an antipyretic effect. Oral administration of the extract reduced intestinal transit time and prevented castor oil-induced diarrhoea in mice. A CNS depressant activity was exhibited by the extract by potentiating the phenobarbitone sleeping time in mice.

KW - Analgesic activity

KW - Anti-inflammatory activity

KW - Antipyretic activity

KW - CNS depressant activity

KW - Psidium guajava

KW - Spasmolytic activity

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U2 - 10.1016/S0367-326X(98)00010-0

DO - 10.1016/S0367-326X(98)00010-0

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EP - 31

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 1

ER -

Pharmacological studies on the leaf of Psidium guajava

Abstract

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