Abstract
L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.
Original language | English |
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Pages (from-to) | 13845-13848 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 54 |
Issue number | 98 |
Early online date | 23 Nov 2018 |
DOIs | |
Publication status | Published - 23 Dec 2018 |
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Dive into the research topics of 'Photoactivatable platinum anticancer complex can generate tryptophan radicals'. Together they form a unique fingerprint.Profiles
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Chris Wedge
- Department of Chemical Sciences - Senior Lecturer in Physical Chemistry
- School of Applied Sciences
- Centre for Functional Materials - Member
- Pharmaceutics and Drug Delivery Centre - Associate Member
- Structural, Molecular and Dynamic Modelling Centre - Associate Member
Person: Academic