Photoactivatable platinum anticancer complex can generate tryptophan radicals

Claudio  Vallotto; Evyenia Shaili; Huayun Shi; Jennifer S Butler; Christopher Wedge; Mark Newton; Peter J. Sadler

doi:10.1039/C8CC06496B

Photoactivatable platinum anticancer complex can generate tryptophan radicals

Claudio Vallotto, Evyenia Shaili, Huayun Shi, Jennifer S Butler, Christopher Wedge, Mark Newton, Peter J. Sadler

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)₂(N₃)₂(OH)₂] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.

Original language	English
Pages (from-to)	13845-13848
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	98
Early online date	23 Nov 2018
DOIs	https://doi.org/10.1039/C8CC06496B
Publication status	Published - 23 Dec 2018

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AU - Vallotto, Claudio

AU - Shaili, Evyenia

AU - Shi, Huayun

AU - Butler, Jennifer S

AU - Wedge, Christopher

AU - Newton, Mark

AU - Sadler, Peter J.

PY - 2018/12/23

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AB - L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.

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Photoactivatable platinum anticancer complex can generate tryptophan radicals

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Chris Wedge

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Photoactivatable platinum anticancer complex can generate tryptophan radicals

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Chris Wedge

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