Photoactivatable platinum anticancer complex can generate tryptophan radicals

Claudio Vallotto, Evyenia Shaili, Huayun Shi, Jennifer S Butler, Christopher Wedge, Mark E Newton, Peter J Sadler

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.
LanguageEnglish
Pages13845-13848
Number of pages4
JournalChemical Communications
Volume54
Issue number98
DOIs
Publication statusPublished - 23 Nov 2018

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Melatonin
Platinum
Tryptophan
Pentagastrin
Hydroxyl Radical
Pyridine
Peptides
Paramagnetic resonance
Irradiation
indole
pyridine

Cite this

Vallotto, C., Shaili, E., Shi, H., Butler, J. S., Wedge, C., Mark E Newton, & Peter J Sadler (2018). Photoactivatable platinum anticancer complex can generate tryptophan radicals. Chemical Communications, 54(98), 13845-13848. https://doi.org/10.1039/C8CC06496B
Vallotto, Claudio ; Shaili, Evyenia ; Shi, Huayun ; Butler, Jennifer S ; Wedge, Christopher ; Mark E Newton ; Peter J Sadler. / Photoactivatable platinum anticancer complex can generate tryptophan radicals. In: Chemical Communications. 2018 ; Vol. 54, No. 98. pp. 13845-13848.
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Vallotto, C, Shaili, E, Shi, H, Butler, JS, Wedge, C, Mark E Newton & Peter J Sadler 2018, 'Photoactivatable platinum anticancer complex can generate tryptophan radicals', Chemical Communications, vol. 54, no. 98, pp. 13845-13848. https://doi.org/10.1039/C8CC06496B

Photoactivatable platinum anticancer complex can generate tryptophan radicals. / Vallotto, Claudio ; Shaili, Evyenia; Shi, Huayun; Butler, Jennifer S; Wedge, Christopher; Mark E Newton; Peter J Sadler.

In: Chemical Communications, Vol. 54, No. 98, 23.11.2018, p. 13845-13848.

Research output: Contribution to journalArticle

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Vallotto C, Shaili E, Shi H, Butler JS, Wedge C, Mark E Newton et al. Photoactivatable platinum anticancer complex can generate tryptophan radicals. Chemical Communications. 2018 Nov 23;54(98):13845-13848. https://doi.org/10.1039/C8CC06496B