L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.
- Department of Chemical Sciences - Senior Lecturer in Physical Chemistry
- School of Applied Sciences
- Centre for Functional Materials - Member
- Pharmaceutics and Drug Delivery Centre - Associate Member
- Structural, Molecular and Dynamic Modelling Centre - Associate Member
Vallotto, C., Shaili, E., Shi, H., Butler, J. S., Wedge, C., Mark E Newton, & Peter J Sadler (2018). Photoactivatable platinum anticancer complex can generate tryptophan radicals. Chemical Communications, 54(98), 13845-13848. https://doi.org/10.1039/C8CC06496B