Photoactivatable platinum anticancer complex can generate tryptophan radicals

Claudio Vallotto, Evyenia Shaili, Huayun Shi, Jennifer S Butler, Christopher Wedge, Mark Newton, Peter J. Sadler

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

L-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.
Original languageEnglish
Pages (from-to)13845-13848
Number of pages4
JournalChemical Communications
Volume54
Issue number98
Early online date23 Nov 2018
DOIs
Publication statusPublished - 23 Dec 2018

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