Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Lili Huang; Peter Kam Keung Leung; Lawrence Cho Cheung Lee; Guang Xi Xu; Yun Wah Lam; Kenneth Kam Wing Lo

doi:10.1039/d2cc02405e

Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Lili Huang, Peter Kam Keung Leung, Lawrence Cho Cheung Lee, Guang Xi Xu, Yun Wah Lam, Kenneth Kam Wing Lo

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(iii) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

Original language	English
Pages (from-to)	10162-10165
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	73
Early online date	8 Aug 2022
DOIs	https://doi.org/10.1039/d2cc02405e
Publication status	Published - 18 Sept 2022
Externally published	Yes

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title = "Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications",

abstract = "We report herein near-infrared (NIR)-emitting cyclometallated iridium(iii) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.",

keywords = "Cysteine, Iridium, cyclometallated iridium polypyridine methylsulfone complex",

author = "Lili Huang and Leung, \{Peter Kam Keung\} and Lee, \{Lawrence Cho Cheung\} and Xu, \{Guang Xi\} and Lam, \{Yun Wah\} and Lo, \{Kenneth Kam Wing\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",

year = "2022",

month = sep,

day = "18",

doi = "10.1039/d2cc02405e",

language = "English",

volume = "58",

pages = "10162--10165",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications. / Huang, Lili; Leung, Peter Kam Keung; Lee, Lawrence Cho Cheung et al.
In: Chemical Communications, Vol. 58, No. 73, 18.09.2022, p. 10162-10165.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

AU - Huang, Lili

AU - Leung, Peter Kam Keung

AU - Lee, Lawrence Cho Cheung

AU - Xu, Guang Xi

AU - Lam, Yun Wah

AU - Lo, Kenneth Kam Wing

PY - 2022/9/18

Y1 - 2022/9/18

N2 - We report herein near-infrared (NIR)-emitting cyclometallated iridium(iii) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

AB - We report herein near-infrared (NIR)-emitting cyclometallated iridium(iii) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

KW - Cysteine

KW - Iridium

KW - cyclometallated iridium polypyridine methylsulfone complex

UR - https://www.scopus.com/pages/publications/85136978489

U2 - 10.1039/d2cc02405e

DO - 10.1039/d2cc02405e

M3 - Article

C2 - 35997227

AN - SCOPUS:85136978489

SN - 1359-7345

VL - 58

SP - 10162

EP - 10165

JO - Chemical Communications

JF - Chemical Communications

IS - 73

ER -

Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Abstract

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